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Literature DB >> 2509153

A prospective, controlled, double-blind, cross-over study of tripterygium wilfodii hook F in treatment of rheumatoid arthritis.

X L Tao, Y Sun, Y Dong, Y L Xiao, D W Hu, Y P Shi, Q L Zhu, H Dai, N Z Zhang.

Abstract

A polyglycosides of Tripterygium wilfodii hook F (TWH) preparation with a code name of T2 is used in the present double-blind, controlled, cross-over study on the treatment of 70 cases of rheumatoid arthritis (RA). An impressive curative effect of T2 is confirmed much more convincingly by the present study than that by the previously reported clinical open trials. The adverse reactions and the probable pharmacological mechanism of T2 are also discussed.

Entities: Disease

Mesh：

Substances：
Drugs, Chinese Herbal

Year: 1989 PMID： 2509153

Source DB: PubMed Journal: Chin Med J (Engl) ISSN： 0366-6999 Impact factor: 2.628

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Cited

23 in total

1. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway.

Authors: Mei Huang; Hailong Zhang; Tao Liu; Dan Tian; Lubing Gu; Muxiang Zhou
Journal: Mol Cancer Ther Date: 2012-12-12 Impact factor: 6.261

2. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.

Authors: G Krishna; K Liu; H Shigemitsu; M Gao; T A Raffin; G D Rosen
Journal: Am J Pathol Date: 2001-03 Impact factor: 4.307

3. Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.

Authors: Hai-tao Meng; Li Zhu; Wan-mao Ni; Liang-shun You; Jie Jin; Wen-bin Qian
Journal: Acta Pharmacol Sin Date: 2011-03-28 Impact factor: 6.150

4. MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer.

Authors: Aimin Yang; Shenghui Qin; Bradley A Schulte; Stephen P Ethier; Kenneth D Tew; Gavin Y Wang
Journal: Cancer Res Date: 2017-09-26 Impact factor: 12.701

5. Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.

Authors: Xin Chen; Takaya Murakami; Joost J Oppenheim; O M Zack Howard
Journal: Blood Date: 2005-06-14 Impact factor: 22.113

Review 6. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety.

Authors: Jun Bao; Sheng-Ming Dai
Journal: Rheumatol Int Date: 2011-03-02 Impact factor: 2.631

A prospective, controlled, double-blind, cross-over study of tripterygium wilfodii hook F in treatment of rheumatoid arthritis.

1. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway.

2. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.

3. Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.

4. MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer.

5. Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.

Review 6. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety.

7. Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.

8. Anti-inflammatory oleanane triterpenes from Tripterygium wilfordii cell suspension cultures by fungal elicitation.

9. Apoptosis of human pancreatic cancer cells induced by Triptolide.

10. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.