| Literature DB >> 25091431 |
Alejandro Bustamante1, Tomás Sobrino2, Dolors Giralt3, Teresa García-Berrocoso3, Victor Llombart3, Iratxe Ugarriza4, Marc Espadaler3, Noelia Rodríguez5, Cathie Sudlow6, Mar Castellanos7, Craig J Smith8, Manuel Rodríguez-Yánez2, Ulrike Waje-Andreassen9, David Tanne10, Jun Oto11, Mark Barber12, Hans Worthmann13, Katja E Wartenberg14, Kyra J Becker15, Baidarbhi Chakraborty16, Seung-Hun Oh17, William N Whiteley6, José Castillo2, Joan Montaner18.
Abstract
We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.Entities:
Keywords: Individual participant data analysis; Interleukin-6; Meta-analysis; Outcome; Post-stroke infection; Stroke
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Year: 2014 PMID： 25091431 DOI： 10.1016/j.jneuroim.2014.07.015
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478