Mehmet Boyraz1, Nihal Hatipoğlu2, Erkan Sarı3, Arzu Akçay4, Necati Taşkın5, Korkut Ulucan6, Teoman Akçay7. 1. Department of Pediatric Endocrinology, Şişli Etfal Education and Research Hospital, Turkey. 2. Medical Faculty, Department of Pediatric Endocrinology, Erciyes University, Turkey. 3. Gulhane Military Medical Faculty, Department of Pediatric Endocrinology, Turkey. 4. Department of Hematology and Oncology, Kanuni Sultan Süleyman Education and Research Hospital, Turkey. 5. Department of Pediatrics, Kanuni Sultan Süleyman Education and Research Hospital, Turkey. 6. Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Üsküdar University, Turkey. Electronic address: korkutulucan@hotmail.com. 7. Department of Pediatric Endocrinology, Bakırköy Dr. Sadi Konuk Education and Research Hospital, Turkey. Electronic address: akteoman@yahoo.com.
Abstract
AIM: To investigate metabolic syndrome (MetS) and MetS criteria, and to establish whether metabolic syndrome criteria were associated with non-alcoholic fatty liver disease (NAFLD) in obese children. METHODS: A total of 451 pubertal obese children (8-18 years old) were enrolled in the study. Patients were divided into three groups according to the degree of steatosis. Antropometric and laboratory measurements of the participants were recorded. RESULTS: Of 451 obese children, 217 (48.1%) were diagnosed as having NAFLD and 96 (21.3%) as having MetS. The frequency of abdominal obesity, hypertension, impaired fasting glucose, hyperinsulinemia, dyslipidemia and type 2 diabetes mellitus (T2DM) were 61.8% (279), 25.7% (116), 4.4% (20), 54.3% (245), 41% (185) and 2.2% (10), respectively. The prevalence of NAFLD among patients with MetS [73% (70/96)], was significantly higher than the frequency of hypertension [55% (53/96)] and abnormalities of glucose metabolism [23% (22/96)], but almost equal to the frequency of dyslipidemia [78% (75/96)]. The prevalence of MetS criteria were higher in patients with NAFLD than those without NAFLD. Except impaired fasting glucose, blood pressure and T2DM significant difference was found between groups for all. It was observed that the number of MetS criteria increased in parallel with the severity of steatosis. CONCLUSION: NAFLD in obese children is strongly associated with multiple MetS criteria. In addition to NAFLD is not only a liver disease, but also early mediator that reflects metabolic disorder, and liver ultrasound can be a useful tool for MetS screening.
AIM: To investigate metabolic syndrome (MetS) and MetS criteria, and to establish whether metabolic syndrome criteria were associated with non-alcoholic fatty liver disease (NAFLD) in obesechildren. METHODS: A total of 451 pubertal obesechildren (8-18 years old) were enrolled in the study. Patients were divided into three groups according to the degree of steatosis. Antropometric and laboratory measurements of the participants were recorded. RESULTS: Of 451 obesechildren, 217 (48.1%) were diagnosed as having NAFLD and 96 (21.3%) as having MetS. The frequency of abdominal obesity, hypertension, impaired fasting glucose, hyperinsulinemia, dyslipidemia and type 2 diabetes mellitus (T2DM) were 61.8% (279), 25.7% (116), 4.4% (20), 54.3% (245), 41% (185) and 2.2% (10), respectively. The prevalence of NAFLD among patients with MetS [73% (70/96)], was significantly higher than the frequency of hypertension [55% (53/96)] and abnormalities of glucose metabolism [23% (22/96)], but almost equal to the frequency of dyslipidemia [78% (75/96)]. The prevalence of MetS criteria were higher in patients with NAFLD than those without NAFLD. Except impaired fasting glucose, blood pressure and T2DM significant difference was found between groups for all. It was observed that the number of MetS criteria increased in parallel with the severity of steatosis. CONCLUSION: NAFLD in obesechildren is strongly associated with multiple MetS criteria. In addition to NAFLD is not only a liver disease, but also early mediator that reflects metabolic disorder, and liver ultrasound can be a useful tool for MetS screening.
Authors: Sung Hyun Lee; Dongwan Kim; Min Young Baek; Hann Tchah; Yeon Sun Kim; Eell Ryoo; Yun Mi Kim Journal: Pediatr Gastroenterol Hepatol Nutr Date: 2015-06-29
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