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Literature DB >> 2509031

Optimal bone resorption by isolated rat osteoclasts requires chloride/bicarbonate exchange.

Abstract

We have examined the effect of DIDS (4,4'-diisothiocyanatostilbene sulfonic acid) a potent, specific and irreversible inhibitor of chloride/bicarbonate exchange on bone resorption by disaggregated rat osteoclasts, using an in vitro bone slice assay. DIDS inhibited bone resorption in concentration dependent fashion, without affecting osteoclast viability or survival on bone slices. The role of anion exchange in the resorptive process is discussed.

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Year: 1989 PMID： 2509031 DOI： 10.1007/bf02556011

Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333

11 in total

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Authors: Z I Cabantchik; P A Knauf; A Rothstein
Journal: Biochim Biophys Acta Date: 1978-09-29

2. Basolateral membrane Na+/H+ antiport, Na+/base cotransport, and Na+-independent Cl-/base exchange in the rabbit S3 proximal tubule.

Authors: I Kurtz
Journal: J Clin Invest Date: 1989-02 Impact factor: 14.808

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Authors: S C Marks; S N Popoff
Journal: Am J Anat Date: 1988-09

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Authors: I A Silver; R J Murrills; D J Etherington
Journal: Exp Cell Res Date: 1988-04 Impact factor: 3.905

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Authors: A Teti; H C Blair; S L Teitelbaum; A J Kahn; C Koziol; J Konsek; A Zambonin-Zallone; P H Schlesinger
Journal: J Clin Invest Date: 1989-01 Impact factor: 14.808

6. Current studies on the location and function of carbonic anhydrase in osteoclasts.

Authors: C V Gay; H Schraer; R E Anderson; H Cao
Journal: Ann N Y Acad Sci Date: 1984 Impact factor: 5.691

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Authors: J R Chaillet; K Amsler; W F Boron
Journal: Proc Natl Acad Sci U S A Date: 1986-01 Impact factor: 11.205

8. Glucocorticoids impair bone resorptive activity and viability of osteoclasts disaggregated from neonatal rat long bones.

Authors: J Tobias; T J Chambers
Journal: Endocrinology Date: 1989-09 Impact factor: 4.736

9. The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones.

Authors: T J Chambers; P M McSheehy; B M Thomson; K Fuller
Journal: Endocrinology Date: 1985-01 Impact factor: 4.736

10. Humoral and ionic regulation of osteoclast acidity.

Authors: R E Anderson; D M Woodbury; W S Jee
Journal: Calcif Tissue Int Date: 1986-10 Impact factor: 4.333

8 in total

1. Pitfalls in pit measurement.

Authors: A Boyde; S J Jones
Journal: Calcif Tissue Int Date: 1991-08 Impact factor: 4.333

2. K+ and Cl- currents in freshly isolated rat osteoclasts.

Authors: S M Sims; M E Kelly; S J Dixon
Journal: Pflugers Arch Date: 1991-10 Impact factor: 3.657

3. Antibodies against ClC7 inhibit extracellular acidification-induced Cl⁻ currents and bone resorption activity in mouse osteoclasts.

Authors: Kimiko Ohgi; Fujio Okamoto; Hiroshi Kajiya; Ryuji Sakagami; Koji Okabe
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2011-01 Impact factor: 3.000