Literature DB >> 25089114

Successful management of a childhood osteosarcoma with epiphysiolysis and distraction osteogenesis.

S F Xu1, X C Yu1, M Xu1, X Chen2.   

Abstract

In an 11-year-old boy with osteosarcoma in the proximal tibia (type iii), 2 cycles of dia chemotherapy (cisplatin, ifosfamide, doxorubicin) were administered preoperatively while epiphysiolysis was performed. Clinical response was determined to be complete by radiography and histopathology. Marginal excision was then performed with preservation of the proximal tibial epiphysis. Metaphyseal reconstruction was performed using distraction osteogenesis. Six cycles of dia chemotherapy were administered postoperatively. Twenty months later, the patient had developed no complications and experienced full bone healing, with no limb discrepancy. In selected adolescent patients with osteosarcoma, in whom the tumour is in full contact with the epiphysis, epiphyseal preservation by epiphysiolysis and reconstruction by distraction osteogenesis can provide an excellent outcome, resulting in a stable reconstruction that functionally restores the native limb.

Entities:  

Keywords:  Osteosarcoma; distraction osteogenesis; epiphysiolysis; epiphysis preservation; limb function; quality of life

Year:  2014        PMID: 25089114      PMCID: PMC4117631          DOI: 10.3747/co.21.1956

Source DB:  PubMed          Journal:  Curr Oncol        ISSN: 1198-0052            Impact factor:   3.677


  20 in total

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3.  Results of using Ilizarov distraction osteogenesis technique for the treatment of cubitus varus deformities in adults.

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Journal:  Arch Orthop Trauma Surg       Date:  2009-05-14       Impact factor: 3.067

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Authors:  D Luis Muscolo; Miguel A Ayerza; Luis A Aponte-Tinao; Maximiliano Ranalletta
Journal:  J Bone Joint Surg Am       Date:  2005-09       Impact factor: 5.284

6.  Free vascularized fibular graft vs. Ilizarov method for post-traumatic tibial bone defect.

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Authors:  H Tsuchiya; T Shirai; A F Morsy; K Sakayama; T Wada; K Kusuzaki; T Sugita; K Tomita
Journal:  J Bone Joint Surg Br       Date:  2008-07
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  3 in total

1.  Cisplatin-Impaired Adipogenic Differentiation of Adipose Mesenchymal Stem Cells1.

Authors:  Yu-Hsun Chang; Hwan-Wun Liu; Tang-Yuan Chu; Yao-Tseng Wen; Rong-Kung Tsai; Dah-Ching Ding
Journal:  Cell Transplant       Date:  2017-02-03       Impact factor: 4.064

2.  Triptolide reduces the viability of osteosarcoma cells by reducing MKP-1 and Hsp70 expression.

Authors:  Lei Zhao; B O Jiang; Dong Wang; Wei Liu; Huawu Zhang; Weisheng Liu; Zhen Qiu
Journal:  Exp Ther Med       Date:  2016-03-15       Impact factor: 2.447

3.  Uncemented three-dimensional-printed prosthetic reconstruction for massive bone defects of the proximal tibia.

Authors:  Minxun Lu; Yongjiang Li; Yi Luo; Wenli Zhang; Yong Zhou; Chongqi Tu
Journal:  World J Surg Oncol       Date:  2018-03-06       Impact factor: 2.754

  3 in total

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