INTRODUCTION: Primary lymphomas of peripheral nerves are extremely rare, and only a few cases have been reported. METHODS: We describe the clinical, neurophysiological, radiological, and pathological findings in a 61-year-old woman affected by primary multifocal lymphoma of the peripheral nervous system without systemic involvement. RESULTS: Fascicular left femoral nerve biopsy was decisive for the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Magnetic resonance imaging, fluorine-18 fluorodeoxyglucose positron emission tomography computed tomography, and nerve ultrasound contributed to the diagnosis. CONCLUSIONS: Primary lymphoma of peripheral nerves (PLPNs) is a rare but potentially treatable condition, which is frequently misdiagnosed. In the literature, there are very few descriptions of PLPNs, most of which are mononeuropathies. The possibility of a neuropathy associated with lymphoma should be considered in patients with poor response to treatment and severe pain symptoms.
INTRODUCTION: Primary lymphomas of peripheral nerves are extremely rare, and only a few cases have been reported. METHODS: We describe the clinical, neurophysiological, radiological, and pathological findings in a 61-year-old woman affected by primary multifocal lymphoma of the peripheral nervous system without systemic involvement. RESULTS:Fascicular left femoral nerve biopsy was decisive for the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Magnetic resonance imaging, fluorine-18 fluorodeoxyglucose positron emission tomography computed tomography, and nerve ultrasound contributed to the diagnosis. CONCLUSIONS:Primary lymphoma of peripheral nerves (PLPNs) is a rare but potentially treatable condition, which is frequently misdiagnosed. In the literature, there are very few descriptions of PLPNs, most of which are mononeuropathies. The possibility of a neuropathy associated with lymphoma should be considered in patients with poor response to treatment and severe pain symptoms.
Authors: Anne Carolus; Roland Schroers; Iris Tischoff; Kirsten Schmieder; Christopher Brenke Journal: Case Reports Plast Surg Hand Surg Date: 2018-10-25
Authors: M Mori; T Izawa; H Sasaki; J Sonoyama; S Nishimura; S Shimamura; T Shimada; T Hasegawa; M Kuwamura; J Yamate Journal: J Comp Pathol Date: 2019-03-15 Impact factor: 1.311