| Literature DB >> 25088334 |
Benito Casu1, Annamaria Naggi2, Giangiacomo Torri2.
Abstract
The sulfated polysaccharide heparin has been used as a life-saving anticoagulant in clinics well before its detailed structure was known. This mini-review is a survey of the evolution in the discovery of the primary and secondary structure of heparin. Highlights in this history include elucidation and synthesis of the specific sequence that binds to antithrombin, the development of low-molecular-weight heparins currently used as antithrombotic drugs, and the most promising start of chemo-enzymatic synthesis. Special emphasis is given to peculiar conformational properties contributing to interaction with proteins that modulate different biological properties.Entities:
Keywords: Active site for antithrombin; Conformations; Heparin oligosaccharides; Heparin structure; Low-molecular-weight heparins; Protein binding
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Year: 2014 PMID： 25088334 DOI： 10.1016/j.carres.2014.06.023
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104