Literature DB >> 25088225

IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation.

Xiao-Mei Deng, Shang-Xue Yan, Wei Wei.   

Abstract

Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.

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Year:  2014        PMID： 25088225      PMCID： PMC4654374          DOI： 10.1038/cmi.2014.58

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  88 in total

1.  IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

Authors:  Mari Strengell; Sampsa Matikainen; Jukka Sirén; Anne Lehtonen; Don Foster; Ilkka Julkunen; Timo Sareneva
Journal:  J Immunol       Date:  2003-06-01       Impact factor: 5.422

2.  Plasma cell precursors: long-distance travelers looking for a home.

Authors:  Sanjiv A Luther
Journal:  Immunity       Date:  2010-07-23       Impact factor: 31.745

3.  Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.

Authors:  Stefan Kuchen; Rachel Robbins; Gary P Sims; Chen Sheng; Terence M Phillips; Peter E Lipsky; Rachel Ettinger
Journal:  J Immunol       Date:  2007-11-01       Impact factor: 5.422

Review 4.  T follicular helper (TFH) cells in normal and dysregulated immune responses.

Authors:  Cecile King; Stuart G Tangye; Charles R Mackay
Journal:  Annu Rev Immunol       Date:  2008       Impact factor: 28.527

5.  IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.

Authors:  Rachel Ettinger; Gary P Sims; Anna-Marie Fairhurst; Rachel Robbins; Yong Sing da Silva; Rosanne Spolski; Warren J Leonard; Peter E Lipsky
Journal:  J Immunol       Date:  2005-12-15       Impact factor: 5.422

6.  IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

Authors:  Deborah Herber; Thomas P Brown; Spencer Liang; Deborah A Young; Mary Collins; Kyri Dunussi-Joannopoulos
Journal:  J Immunol       Date:  2007-03-15       Impact factor: 5.422

7.  Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.

Authors:  Nathalie Simard; Danijela Konforte; Anne H Tran; Jessica Esufali; Warren J Leonard; Christopher J Paige
Journal:  J Immunol       Date:  2011-03-23       Impact factor: 5.422

8.  A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

Authors:  Carola G Vinuesa; Matthew C Cook; Constanza Angelucci; Vicki Athanasopoulos; Lixin Rui; Kim M Hill; Di Yu; Heather Domaschenz; Belinda Whittle; Teresa Lambe; Ian S Roberts; Richard R Copley; John I Bell; Richard J Cornall; Christopher C Goodnow
Journal:  Nature       Date:  2005-05-26       Impact factor: 49.962

9.  Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.

Authors:  Jérôme Pène; Jean-François Gauchat; Sandrine Lécart; Elodie Drouet; Paul Guglielmi; Vera Boulay; Adriana Delwail; Don Foster; Jean-Claude Lecron; Hans Yssel
Journal:  J Immunol       Date:  2004-05-01       Impact factor: 5.422

Review 10.  The role of IL-21 in regulating B-cell function in health and disease.

Authors:  Rachel Ettinger; Stefan Kuchen; Peter E Lipsky
Journal:  Immunol Rev       Date:  2008-06       Impact factor: 12.988
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  10 in total

1.  Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation.

Authors:  Yanwei Wu; Shijun He; Bingxin Bai; Luyao Zhang; Lu Xue; Zemin Lin; Xiaoqian Yang; Fenghua Zhu; Peilan He; Wei Tang; Jianping Zuo
Journal:  Cell Mol Immunol       Date:  2015-03-16       Impact factor: 11.530

2.  Cytokines (IL-15, IL-21, and IFN-γ) in rheumatoid arthritis: association with positivity to autoantibodies (RF, anti-CCP, anti-MCV, and anti-PADI4) and clinical activity.

Authors:  Itzel Viridiana Reyes-Pérez; Pedro Ernesto Sánchez-Hernández; José Francisco Muñoz-Valle; Gloria Esther Martínez-Bonilla; Trinidad García-Iglesias; Verónica González-Díaz; Samuel García-Arellano; Sergio Cerpa-Cruz; Julissa Polanco-Cruz; María Guadalupe Ramírez-Dueñas
Journal:  Clin Rheumatol       Date:  2019-07-17       Impact factor: 2.980

Review 3.  The JAK/STAT signaling pathway: from bench to clinic.

Authors:  Xiaoyi Hu; Jing Li; Maorong Fu; Xia Zhao; Wei Wang
Journal:  Signal Transduct Target Ther       Date:  2021-11-26

4.  Contribution and underlying mechanisms of CXCR4 overexpression in patients with systemic lupus erythematosus.

Authors:  Li-Dan Zhao; Di Liang; Xiang-Ni Wu; Yang Li; Jing-Wen Niu; Chen Zhou; Li Wang; Hua Chen; Wen-Jie Zheng; Yun-Yun Fei; Fu-Lin Tang; Yong-Zhe Li; Feng-Chun Zhang; Wei He; Xue-Tao Cao; Xuan Zhang
Journal:  Cell Mol Immunol       Date:  2016-09-26       Impact factor: 11.530

5.  Unique Sjögren's syndrome patient subsets defined by molecular features.

Authors:  Judith A James; Joel M Guthridge; Hua Chen; Rufei Lu; Rebecka L Bourn; Krista Bean; Melissa E Munroe; Miles Smith; Eliza Chakravarty; Alan N Baer; Ghaith Noaiseh; Ann Parke; Karen Boyle; Lynette Keyes-Elstein; Andreea Coca; Tammy Utset; Mark C Genovese; Virginia Pascual; Paul J Utz; V Michael Holers; Kevin D Deane; Kathy L Sivils; Teresa Aberle; Daniel J Wallace; James McNamara; Nathalie Franchimont; E William St Clair
Journal:  Rheumatology (Oxford)       Date:  2020-04-01       Impact factor: 7.580

6.  Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production.

Authors:  Sumbul Afroz; Srikanth Battu; Shaikh Matin; Sabrina Solouki; Jessica P Elmore; Gillipsie Minhas; Weishan Huang; Avery August; Nooruddin Khan
Journal:  Sci Signal       Date:  2019-11-12       Impact factor: 8.192

Review 7.  Pathways leading to an immunological disease: systemic lupus erythematosus.

Authors:  Olga Zharkova; Teja Celhar; Petra D Cravens; Anne B Satterthwaite; Anna-Marie Fairhurst; Laurie S Davis
Journal:  Rheumatology (Oxford)       Date:  2017-04-01       Impact factor: 7.580

8.  B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.

Authors:  John S Yi; Melissa A Russo; Janice M Massey; Vern Juel; Lisa D Hobson-Webb; Karissa Gable; Shruti M Raja; Kristina Balderson; Kent J Weinhold; Jeffrey T Guptill
Journal:  Front Neurol       Date:  2017-02-10       Impact factor: 4.003

9.  Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3.

Authors:  Se Gwang Jang; Jaeseon Lee; Seung-Min Hong; Young-Seok Song; Min Jun Kim; Seung-Ki Kwok; Mi-La Cho; Sung-Hwan Park
Journal:  J Transl Med       Date:  2021-02-25       Impact factor: 5.531

Review 10.  Signaling networks controlling ID and E protein activity in T cell differentiation and function.

Authors:  Sung-Min Hwang; Sin-Hyeog Im; Dipayan Rudra
Journal:  Front Immunol       Date:  2022-08-02       Impact factor: 8.786
  10 in total

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