Literature DB >> 25087623

Lymphangiogenesis and metastasis--a closer look at the neuropilin/semaphorin3 axis.

Matthew T Migliozzi1, Patrick Mucka1, Diane R Bielenberg2.   

Abstract

Metastasis is the leading cause of cancer-related deaths. Understanding how the lymphatic system responds to its environment and local stimuli may lead to therapies to combat metastasis and other lymphatic-associated diseases. This review compares lymphatic vessels and blood vessels, discusses markers of lymphatic vasculature, and elucidates some of the signaling motifs involved in lymphangiogenesis. Recent progress implicating the neuropilin and semaphorin axes in this process is discussed.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cancer; Lymphangiogenesis; Metastasis; Neuropilin; Semaphorin

Mesh：

Substances：

Year:  2014        PMID： 25087623      PMCID： PMC4268048          DOI： 10.1016/j.mvr.2014.07.006

Source DB:  PubMed          Journal:  Microvasc Res        ISSN： 0026-2862            Impact factor:   3.514


  109 in total

1.  Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype.

Authors:  Diane R Bielenberg; Yasuhiro Hida; Akio Shimizu; Arja Kaipainen; Michael Kreuter; Caroline Choi Kim; Michael Klagsbrun
Journal:  J Clin Invest       Date:  2004-11       Impact factor: 14.808

2.  Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.

Authors:  S Soker; S Takashima; H Q Miao; G Neufeld; M Klagsbrun
Journal:  Cell       Date:  1998-03-20       Impact factor: 41.582

3.  NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation.

Authors:  Sina Koch; Laurens A van Meeteren; Eric Morin; Chiara Testini; Simone Weström; Hanna Björkelund; Sébastien Le Jan; Jeremy Adler; Philipp Berger; Lena Claesson-Welsh
Journal:  Dev Cell       Date:  2014-03-20       Impact factor: 12.270

4.  Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1.

Authors:  Claudia Prahst; Mélanie Héroult; Anthony A Lanahan; Noa Uziel; Ofra Kessler; Niva Shraga-Heled; Michael Simons; Gera Neufeld; Hellmut G Augustin
Journal:  J Biol Chem       Date:  2008-07-15       Impact factor: 5.157

5.  Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to semaphorin 3F.

Authors:  Elena Geretti; Akio Shimizu; Peter Kurschat; Michael Klagsbrun
Journal:  J Biol Chem       Date:  2007-06-26       Impact factor: 5.157

6.  Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema.

Authors:  Anne Le; Rachel Zielinski; Chaoxia He; Michael T Crow; Shyam Biswal; Rubin M Tuder; Patrice M Becker
Journal:  Am J Respir Crit Care Med       Date:  2009-06-11       Impact factor: 21.405

7.  A requirement for neuropilin-1 in embryonic vessel formation.

Authors:  T Kawasaki; T Kitsukawa; Y Bekku; Y Matsuda; M Sanbo; T Yagi; H Fujisawa
Journal:  Development       Date:  1999-11       Impact factor: 6.868

8.  A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.

Authors:  René Hägerling; Cathrin Pollmann; Martin Andreas; Christian Schmidt; Harri Nurmi; Ralf H Adams; Kari Alitalo; Volker Andresen; Stefan Schulte-Merker; Friedemann Kiefer
Journal:  EMBO J       Date:  2013-01-08       Impact factor: 11.598

9.  Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis.

Authors:  Alessandro Fantin; Birger Herzog; Marwa Mahmoud; Maiko Yamaji; Alice Plein; Laura Denti; Christiana Ruhrberg; Ian Zachary
Journal:  Development       Date:  2014-01-08       Impact factor: 6.868

10.  Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer.

Authors:  Jacqueline Banyard; Ivy Chung; Matthew Migliozzi; Derek T Phan; Arianne M Wilson; Bruce R Zetter; Diane R Bielenberg
Journal:  BMC Cancer       Date:  2014-05-30       Impact factor: 4.430
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  6 in total

Review 1.  The role of EMT and MET in cancer dissemination.

Authors:  Jacqueline Banyard; Diane R Bielenberg
Journal:  Connect Tissue Res       Date:  2015-08-20       Impact factor: 3.417

2.  Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.

Authors:  Patrick Mucka; Nicholas Levonyak; Elena Geretti; Bernadette M M Zwaans; Xiaoran Li; Irit Adini; Michael Klagsbrun; Rosalyn M Adam; Diane R Bielenberg
Journal:  Am J Pathol       Date:  2016-10-14       Impact factor: 4.307

Review 3.  The Contribution of Angiogenesis to the Process of Metastasis.

Authors:  Diane R Bielenberg; Bruce R Zetter
Journal:  Cancer J       Date:  2015 Jul-Aug       Impact factor: 3.360

4.  Genotyping and mRNA profiling reveal actionable molecular targets in biliary tract cancers.

Authors:  Kyriaki Papadopoulou; Samuel Murray; Kyriaki Manousou; Ioannis Tikas; Christos Dervenis; Joseph Sgouros; Dimitra Rontogianni; Sotirios Lakis; Mattheos Bobos; Christos Poulios; Stavroula Pervana; Georgios Lazaridis; George Fountzilas; Vassiliki Kotoula
Journal:  Am J Cancer Res       Date:  2018-01-01       Impact factor: 6.166

Review 5.  Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer.

Authors:  Pratiek N Matkar; Eric D Jong; Ramya Ariyagunarajah; Gerald J Prud'homme; Krishna K Singh; Howard Leong-Poi
Journal:  Cancer Med       Date:  2018-09-14       Impact factor: 4.452

Review 6.  Neuropilins in the Context of Tumor Vasculature.

Authors:  Stephan Niland; Johannes A Eble
Journal:  Int J Mol Sci       Date:  2019-02-01       Impact factor: 5.923
  6 in total

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