Literature DB >> 2508739

DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?

P Workman1, M I Walton, G Powis, J J Schlager.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2508739      PMCID： PMC2247312          DOI： 10.1038/bjc.1989.364

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


× No keyword cloud information.
  21 in total

1.  Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.

Authors:  S R Keyes; S Rockwell; A C Sartorelli
Journal:  Cancer Res       Date:  1985-01       Impact factor: 12.701

2.  One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase).

Authors:  T Iyanagi; I Yamazaki
Journal:  Biochim Biophys Acta       Date:  1970-09-01

3.  Walker carcinosarcoma 256 in study of anticancer agents. I. Method for simultaneous assessment of therapeutic value and toxicity.

Authors:  V M Rosenoer; B C Mitchley; F J Roe; T A Connors
Journal:  Cancer Res       Date:  1966-08       Impact factor: 12.701

4.  DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation.

Authors:  C Lind; P Hochstein; L Ernster
Journal:  Arch Biochem Biophys       Date:  1982-06       Impact factor: 4.013

5.  NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

Authors:  N R Bachur; S L Gordon; M V Gee; H Kon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

6.  Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro.

Authors:  S R Keyes; S Rockwell; A C Sartorelli
Journal:  Cancer Res       Date:  1985-08       Impact factor: 12.701

7.  The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

Authors:  H Thor; M T Smith; P Hartzell; G Bellomo; S A Jewell; S Orrenius
Journal:  J Biol Chem       Date:  1982-10-25       Impact factor: 5.157

8.  Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

Authors:  S S Pan; P A Andrews; C J Glover; N R Bachur
Journal:  J Biol Chem       Date:  1984-01-25       Impact factor: 5.157

9.  Induction of DNA damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes.

Authors:  H Morrison; B Jernström; M Nordenskjöld; H Thor; S Orrenius
Journal:  Biochem Pharmacol       Date:  1984-06-01       Impact factor: 5.858

10.  Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions.

Authors:  R S Marshall; M C Paterson; A M Rauth
Journal:  Br J Cancer       Date:  1989-03       Impact factor: 7.640
View more
  11 in total

1.  Porfiromycin disposition in oxygen-modulated P388 cells.

Authors:  S S Pan
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

2.  Oncogenic potential of bifunctional bioreductive drugs.

Authors:  T K Hei; S X Liu; E J Hall
Journal:  Br J Cancer Suppl       Date:  1996-07

3.  Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones.

Authors:  D L Gustafson; H D Beall; E M Bolton; D Ross; C A Waldren
Journal:  Mol Pharmacol       Date:  1996-10       Impact factor: 4.436

4.  The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells.

Authors:  S S Pan; S A Akman; G L Forrest; C Hipsher; R Johnson
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 5.  DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

Authors:  D Ross; D Siegel; H Beall; A S Prakash; R T Mulcahy; N W Gibson
Journal:  Cancer Metastasis Rev       Date:  1993-06       Impact factor: 9.264

6.  Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.

Authors:  Y Shao; L Pardini; R S Pardini
Journal:  Lipids       Date:  1995-11       Impact factor: 1.880

7.  In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

Authors:  R M Phillips; P B Hulbert; M C Bibby; N R Sleigh; J A Double
Journal:  Br J Cancer       Date:  1992-03       Impact factor: 7.640

Review 8.  The experimental development of bioreductive drugs and their role in cancer therapy.

Authors:  P Workman; I J Stratford
Journal:  Cancer Metastasis Rev       Date:  1993-06       Impact factor: 9.264

9.  Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells.

Authors:  M B Parliament; L I Wiebe; A J Franko
Journal:  Br J Cancer       Date:  1992-12       Impact factor: 7.640

10.  DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

Authors:  J A Plumb; M Gerritsen; P Workman
Journal:  Br J Cancer       Date:  1994-12       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.