Literature DB >> 25086750

Integrating germline and somatic data towards a personalized cancer medicine.

Miguel Angel Pujana1.   

Abstract

In recent years there have been major advances in the knowledge of the genetic alterations that drive cancer susceptibility and progression. However, the molecular links between these alteration levels (i.e., germline for susceptibility and somatic for progression) remain mostly unknown. Here, the potential of integrating germline and somatic data for a comprehensive and personalized cancer medicine is discussed.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cancer; genetics; germline; personalized medicine; risk; somatic

Mesh：

Year:  2014        PMID： 25086750     DOI： 10.1016/j.molmed.2014.05.004

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  5 in total

Review 1.  DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.

Authors:  Mariamena Arbitrio; Maria Teresa Di Martino; Francesca Scionti; Giuseppe Agapito; Pietro Hiram Guzzi; Mario Cannataro; Pierfrancesco Tassone; Pierosandro Tagliaferri
Journal:  Oncotarget       Date:  2016-08-16

2.  Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer.

Authors:  Runmin Wei; Immaculata De Vivo; Sijia Huang; Xun Zhu; Harvey Risch; Jason H Moore; Herbert Yu; Lana X Garmire
Journal:  Oncotarget       Date:  2016-08-23

3.  A catalog of curated breast cancer genes.

Authors:  Jan Benada; Jayashree Vijay Thatte; Muthiah Bose; Savvas Kinalis; Bent Ejlertsen; Finn Cilius Nielsen; Claus Storgaard Sørensen; Maria Rossing
Journal:  Breast Cancer Res Treat       Date:  2021-11-10       Impact factor: 4.872

4.  Modification of BRCA1-associated breast cancer risk by HMMR overexpression.

Authors:  Francesca Mateo; Zhengcheng He; Lin Mei; Gorka Ruiz de Garibay; Carmen Herranz; Nadia García; Amanda Lorentzian; Alexandra Baiges; Eline Blommaert; Antonio Gómez; Oriol Mirallas; Anna Garrido-Utrilla; Luis Palomero; Roderic Espín; Ana I Extremera; M Teresa Soler-Monsó; Anna Petit; Rong Li; Joan Brunet; Ke Chen; Susanna Tan; Connie J Eaves; Curtis McCloskey; Razq Hakem; Rama Khokha; Philipp F Lange; Conxi Lázaro; Christopher A Maxwell; Miquel Angel Pujana
Journal:  Nat Commun       Date:  2022-04-07       Impact factor: 14.919

5.  Distinct Genomic Alterations in Prostate Tumors from African American Men.

Authors:  Zhaoming Wang
Journal:  EBioMedicine       Date:  2015-11-19       Impact factor: 8.143
  5 in total

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