Immune-based interventions to prevent postnatal HIV-1 transmission.

Despite global scale-up in antiretroviral-based prevention of mother-to-child transmission services, more than 250 000 infants become infected with HIV-1 each year. Breast milk transmission is responsible for almost half of these infections. The development of alternative strategies to prevent postnatal HIV-1 transmission is imperative to achieve a generation free of HIV-1.