J Christiaan van Denderen1, Ingrid M Visman1, Michael T Nurmohamed1, Maria S A Suttorp-Schulten1, Irene E van der Horst-Bruinsma2. 1. From the Department of Rheumatology, Jan van Breemen Research Institute Reade, and Department of Rheumatology, VU University Medical Center; and Department of Ophthalmology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.J.C. van Denderen, MD; I.M. Visman, Department of Rheumatology, Jan van Breemen Research Institute Reade; M.T. Nurmohamed, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute Reade, and Department of Rheumatology, VU University Medical Center; M.S.A. Suttorp-Schulten, MD, PhD, Department of Ophthalmology, Onze Lieve Vrouwe Gasthuis; I.E. van der Horst-Bruinsma, MD, PhD, Department of Rheumatology, VU University Medical Center. 2. From the Department of Rheumatology, Jan van Breemen Research Institute Reade, and Department of Rheumatology, VU University Medical Center; and Department of Ophthalmology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.J.C. van Denderen, MD; I.M. Visman, Department of Rheumatology, Jan van Breemen Research Institute Reade; M.T. Nurmohamed, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute Reade, and Department of Rheumatology, VU University Medical Center; M.S.A. Suttorp-Schulten, MD, PhD, Department of Ophthalmology, Onze Lieve Vrouwe Gasthuis; I.E. van der Horst-Bruinsma, MD, PhD, Department of Rheumatology, VU University Medical Center. ie.vanderhorst@vumc.nl.
Abstract
OBJECTIVE: To investigate whether use of adalimumab decreases the frequency of attacks of anterior uveitis (AU) in patients with ankylosing spondylitis (AS). METHODS: Consecutive patients with AS, visiting an outpatient clinic and treated for at least 12 weeks with adalimumab, were enrolled. The number of attacks of AU in the year before start and during treatment were assessed by patient history and ophthalmological controls. RESULTS: In the 77 patients a total of 52 AU attacks occurred in the year before baseline (68 attacks per 100 patient-yrs), whereas during adalimumab treatment 19 attacks were seen (14 per 100 patient-yrs; reduction rate 80%). Twenty-six patients with AU in the year before start of adalimumab treatment had recurrent attacks, with a median number of 2.0 AU attacks per year [interquartile range (IQR) 1.00-3.00], whereas during treatment this decreased to 10 patients with a median number of 0.56 attacks per year (IQR 0.30-0.75). Hence, the number of attacks per year decreased by 72% (p = 0.000). CONCLUSION: In patients with AS, a significant reduction in the number of AU attacks, as well as in the number of attacks per patient, was observed during adalimumab treatment.
OBJECTIVE: To investigate whether use of adalimumab decreases the frequency of attacks of anterior uveitis (AU) in patients with ankylosing spondylitis (AS). METHODS: Consecutive patients with AS, visiting an outpatient clinic and treated for at least 12 weeks with adalimumab, were enrolled. The number of attacks of AU in the year before start and during treatment were assessed by patient history and ophthalmological controls. RESULTS: In the 77 patients a total of 52 AU attacks occurred in the year before baseline (68 attacks per 100 patient-yrs), whereas during adalimumab treatment 19 attacks were seen (14 per 100 patient-yrs; reduction rate 80%). Twenty-six patients with AU in the year before start of adalimumab treatment had recurrent attacks, with a median number of 2.0 AU attacks per year [interquartile range (IQR) 1.00-3.00], whereas during treatment this decreased to 10 patients with a median number of 0.56 attacks per year (IQR 0.30-0.75). Hence, the number of attacks per year decreased by 72% (p = 0.000). CONCLUSION: In patients with AS, a significant reduction in the number of AU attacks, as well as in the number of attacks per patient, was observed during adalimumab treatment.
Authors: Inês Leal; Filipe B Rodrigues; David Cordeiro Sousa; Gonçalo S Duarte; Vasco C Romão; Carlos Marques-Neves; João Costa; João Eurico Fonseca Journal: Front Med (Lausanne) Date: 2019-05-24
Authors: Ping Chen; Cristhian A Urzua; Jared E Knickelbein; Jane S Kim; Zhiyu Li; Susan Hannes; David Kuo; Benjamin Chaigne-Delalande; Karen Armbrust; William Tucker; Baoying Liu; Elvira Agrón; H Nida Sen; Robert B Nussenblatt Journal: Invest Ophthalmol Vis Sci Date: 2016-04 Impact factor: 4.799
Authors: Irene van der Horst-Bruinsma; Rianne van Bentum; Frank D Verbraak; Thomas Rath; James T Rosenbaum; Maria Misterska-Skora; Bengt Hoepken; Oscar Irvin-Sellers; Brenda VanLunen; Lars Bauer; Martin Rudwaleit Journal: RMD Open Date: 2020-04