Nicolas Ballon1, Paul Brunault2, Samuele Cortese3. 1. CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France CHRU de Tours, Équipe de Liaison et de Soins en Addictologie, Tours, France Université François Rabelais de Tours, Tours, France UMR INSERM U930 ERL, Tours, France. 2. CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France CHRU de Tours, Équipe de Liaison et de Soins en Addictologie, Tours, France Université François Rabelais de Tours, Département de Psychologie, EA 2114, Psychologie des Ages de la Vie, Tours, France. 3. Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK School of Medicine, University of Nottingham, UK samuele.cortese@gmail.com.
Abstract
OBJECTIVE: To compare measures of sensation seeking in a clinical group of cocaine-dependent (CD) patients with and without a history of probable childhood ADHD and in non-cocaine-dependent (NCD) healthy volunteers. METHOD: Patients (n = 75; 42 with and 33 without probable childhood ADHD) and comparisons (n = 84) were assessed with the Diagnostic Interview for Genetic Studies, the Wender Utah Rating Scale for childhood ADHD, and the Zuckerman Seeking Sensation Scale. RESULTS: We found significantly higher prevalence rates of probable childhood ADHD in CD versus NCD (p < .001). The mean total scores of sensation seeking were significantly higher in CD versus NCD participants (p < .001) as well as in CD patients with versus those without a probable history of childhood ADHD (p < .001). CONCLUSION: Our study sets the basis for longitudinal investigation assessing whether the persistence of high level of sensation seeking in adults with childhood ADHD contributes to the transition to cocaine dependence.
OBJECTIVE: To compare measures of sensation seeking in a clinical group of cocaine-dependent (CD) patients with and without a history of probable childhood ADHD and in non-cocaine-dependent (NCD) healthy volunteers. METHOD:Patients (n = 75; 42 with and 33 without probable childhood ADHD) and comparisons (n = 84) were assessed with the Diagnostic Interview for Genetic Studies, the Wender Utah Rating Scale for childhood ADHD, and the Zuckerman Seeking Sensation Scale. RESULTS: We found significantly higher prevalence rates of probable childhood ADHD in CD versus NCD (p < .001). The mean total scores of sensation seeking were significantly higher in CD versus NCD participants (p < .001) as well as in CDpatients with versus those without a probable history of childhood ADHD (p < .001). CONCLUSION: Our study sets the basis for longitudinal investigation assessing whether the persistence of high level of sensation seeking in adults with childhood ADHD contributes to the transition to cocaine dependence.
Authors: Roxanne W Hook; Jon E Grant; Konstantinos Ioannidis; Jeggan Tiego; Murat Yücel; Paul Wilkinson; Samuel R Chamberlain Journal: Neurosci Biobehav Rev Date: 2020-10-25 Impact factor: 8.989