BACKGROUND: ERCP is frequently used in patients with primary sclerosing cholangitis (PSC) for cancer surveillance and treatment of dominant strictures. OBJECTIVE: To evaluate the prevalence and risk factors for ERCP-related adverse events in patients with PSC. DESIGN: Retrospective analysis of ERCPs performed from 1998 to 2012. SETTING: Referral center. PATIENTS: A total of 294 consecutive patients with PSC who underwent a total of 657 ERCPs. INTERVENTIONS: ERCP. MAIN OUTCOME MEASUREMENTS: ERCP-related adverse events and predictive factors were determined by univariate and multivariate analyses. RESULTS: ERCP use in patients with PSC showed a significant increase during the second half of the study period (2006-2012) compared with the first half (1998-2005) (437 vs 220 procedures; P = .04). Primary cannulation was successful in 634 procedures (96.6%) or in 271 of 294 patients (92.2%). Access to the bile duct was achieved with a needle-knife in 19 procedures (2.9%), whereas ERCP was unsuccessful in 4 of 657 procedures (0.6%), and successful percutaneous drainage was performed. Post-ERCP pancreatitis (PEP) was diagnosed in 8 (1.2%), cholangitis in 16 (2.4%), and bleeding in 4 (0.7%) procedures. Overall, risk of any adverse event was 28 of 657 (4.3%) procedures. On multivariate analysis, performing biliary sphincterotomy (odds ratio [OR] 5.04; 95% confidence interval [CI], 2.01-12.60; P = .001) and passage of a guidewire into the pancreatic duct (OR 4.54; 95% CI, 1.44-14.30; P = .010) were independently associated with an increased risk of any adverse event. LIMITATIONS: Retrospective study. CONCLUSION: Cholangitis appears to be the most common adverse event despite intraprocedural antibiotic use. There was a low risk of adverse events in patients with PSC undergoing ERCP.
BACKGROUND: ERCP is frequently used in patients with primary sclerosing cholangitis (PSC) for cancer surveillance and treatment of dominant strictures. OBJECTIVE: To evaluate the prevalence and risk factors for ERCP-related adverse events in patients with PSC. DESIGN: Retrospective analysis of ERCPs performed from 1998 to 2012. SETTING: Referral center. PATIENTS: A total of 294 consecutive patients with PSC who underwent a total of 657 ERCPs. INTERVENTIONS: ERCP. MAIN OUTCOME MEASUREMENTS: ERCP-related adverse events and predictive factors were determined by univariate and multivariate analyses. RESULTS: ERCP use in patients with PSC showed a significant increase during the second half of the study period (2006-2012) compared with the first half (1998-2005) (437 vs 220 procedures; P = .04). Primary cannulation was successful in 634 procedures (96.6%) or in 271 of 294 patients (92.2%). Access to the bile duct was achieved with a needle-knife in 19 procedures (2.9%), whereas ERCP was unsuccessful in 4 of 657 procedures (0.6%), and successful percutaneous drainage was performed. Post-ERCP pancreatitis (PEP) was diagnosed in 8 (1.2%), cholangitis in 16 (2.4%), and bleeding in 4 (0.7%) procedures. Overall, risk of any adverse event was 28 of 657 (4.3%) procedures. On multivariate analysis, performing biliary sphincterotomy (odds ratio [OR] 5.04; 95% confidence interval [CI], 2.01-12.60; P = .001) and passage of a guidewire into the pancreatic duct (OR 4.54; 95% CI, 1.44-14.30; P = .010) were independently associated with an increased risk of any adverse event. LIMITATIONS: Retrospective study. CONCLUSION:Cholangitis appears to be the most common adverse event despite intraprocedural antibiotic use. There was a low risk of adverse events in patients with PSC undergoing ERCP.
Authors: Vilja Koskensalo; Andrea Tenca; Marianne Udd; Outi Lindström; Mia Rainio; Kalle Jokelainen; Leena Kylänpää; Martti Färkkilä Journal: United European Gastroenterol J Date: 2020-03-08 Impact factor: 4.623
Authors: Amaninder S Dhaliwal; Yassin Naga; Daryl Ramai; Syed M Saghir; Sarav G Daid; Banreet Dhindsa; Andrew Ofosu; Pushpak Taunk Journal: Ann Gastroenterol Date: 2022-03-25
Authors: Udayakumar Navaneethan; Dennisdhilak Lourdusamy; Norma G Gutierrez; Xiang Zhu; John J Vargo; Mansour A Parsi Journal: Endosc Int Open Date: 2017-08-07