BACKGROUND: Self-expandable metal stent (SEMS) placement and palliative gastrojejunostomy (GJJ) are palliative treatment options for malignant gastric outlet obstruction. OBJECTIVE: To compare clinical outcomes of palliative treatments for gastric outlet obstruction caused by unresectable gastric cancer. DESIGN: Retrospective study. SETTING: University-affiliated tertiary-care hospital in the Republic of Korea. PATIENTS: Two hundred fifty-six patients with gastric outlet obstruction caused by unresectable gastric cancer. INTERVENTION: SEMS placement and palliative GJJ. MAIN OUTCOME MEASUREMENTS: Patency duration and overall survival duration. RESULTS: In total, 217 and 39 patients underwent SEMS placement and palliative GJJ, respectively, as an initial palliative treatment. Treatment modality affected reobstruction after clinical success (hazard ratio [HR] [95% confidence interval {CI}], 0.5 [0.3-0.8] of palliative GJJ). In addition, carcinomatosis with ascites was an independent associated factor of clinical success and reobstruction (HR [95% CI], 0.3 [0.1-0.7] and 1.4 [1.0-2.0], respectively). In a subgroup of patients with good performance who had neither carcinomatosis nor ascites, patency duration and overall survival duration did not differ between the 2 groups (P = .079 and P = .290, respectively). In patients with good performance who had carcinomatosis without ascites, patency duration was longer in the palliative GJJ group than in the SEMS placement group (P = .016). Overall survival, however, did not differ between the 2 groups (P = .062). In a subgroup of patients with good performance who had carcinomatosis with ascites, both patency duration and overall survival were longer in the palliative GJJ group than in the SEMS placement group (P = .007 and P = .012, respectively). LIMITATIONS: Nonrandomized, retrospective study. CONCLUSION: Long-term clinical outcomes of the palliative treatment modality for gastric outlet obstruction caused by unresectable gastric cancer were affected by carcinomatosis and ascites status.
BACKGROUND: Self-expandable metal stent (SEMS) placement and palliative gastrojejunostomy (GJJ) are palliative treatment options for malignant gastric outlet obstruction. OBJECTIVE: To compare clinical outcomes of palliative treatments for gastric outlet obstruction caused by unresectable gastric cancer. DESIGN: Retrospective study. SETTING: University-affiliated tertiary-care hospital in the Republic of Korea. PATIENTS: Two hundred fifty-six patients with gastric outlet obstruction caused by unresectable gastric cancer. INTERVENTION: SEMS placement and palliative GJJ. MAIN OUTCOME MEASUREMENTS: Patency duration and overall survival duration. RESULTS: In total, 217 and 39 patients underwent SEMS placement and palliative GJJ, respectively, as an initial palliative treatment. Treatment modality affected reobstruction after clinical success (hazard ratio [HR] [95% confidence interval {CI}], 0.5 [0.3-0.8] of palliative GJJ). In addition, carcinomatosis with ascites was an independent associated factor of clinical success and reobstruction (HR [95% CI], 0.3 [0.1-0.7] and 1.4 [1.0-2.0], respectively). In a subgroup of patients with good performance who had neither carcinomatosis nor ascites, patency duration and overall survival duration did not differ between the 2 groups (P = .079 and P = .290, respectively). In patients with good performance who had carcinomatosis without ascites, patency duration was longer in the palliative GJJ group than in the SEMS placement group (P = .016). Overall survival, however, did not differ between the 2 groups (P = .062). In a subgroup of patients with good performance who had carcinomatosis with ascites, both patency duration and overall survival were longer in the palliative GJJ group than in the SEMS placement group (P = .007 and P = .012, respectively). LIMITATIONS: Nonrandomized, retrospective study. CONCLUSION: Long-term clinical outcomes of the palliative treatment modality for gastric outlet obstruction caused by unresectable gastric cancer were affected by carcinomatosis and ascites status.
Authors: Alisa N Blumenthaler; Naruhiko Ikoma; Mariela Blum; Prajnan Das; Bruce D Minsky; Paul F Mansfield; Jaffer A Ajani; Brian D Badgwell Journal: J Surg Oncol Date: 2020-08-18 Impact factor: 3.454
Authors: Rajesh Krishnamoorthi; Shivanand Bomman; Petros Benias; Richard A Kozarek; Joyce A Peetermans; Edmund McMullen; Ornela Gjata; Shayan S Irani Journal: Endosc Int Open Date: 2022-06-10
Authors: Seung Hyeon Jang; Hyuk Lee; Byung-Hoon Min; Su Mi Kim; Hye Seung Kim; Keumhee C Carriere; Yang Won Min; Jun Haeng Lee; Jae J Kim Journal: Surg Endosc Date: 2017-03-09 Impact factor: 4.584