Laura Tapiovaara1, Liisa Lehtoranta2, Elisa Swanljung3, Harri Mäkivuokko4, Sanna Laakso5, Merja Roivainen6, Riitta Korpela7, Anne Pitkäranta8. 1. Department of Otorhinolaryngology, Helsinki University Central Hospital and University of Helsinki, PO Box 220, FI-00290 Helsinki, Finland. Electronic address: laura.k.tapiovaara@helsinki.fi. 2. University of Helsinki, Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, PO Box 64, FI-00014 Helsinki, Finland. Electronic address: liisa.lehtoranta@helsinki.fi. 3. Department of Otorhinolaryngology, Helsinki University Central Hospital and University of Helsinki, PO Box 220, FI-00290 Helsinki, Finland. Electronic address: elisa.swanljung@helsinki.fi. 4. Valio Limited, PO Box 10, Valio, FI-00039 Helsinki, Finland. Electronic address: harri.makivuokko@valio.fi. 5. Mobidiag Limited, Keilaranta 16A, FI-02150 Espoo, Finland. Electronic address: sanna.laakso@mobidiag.com. 6. Virology Unit, Division of Health Protection, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), PO Box 30, 00271 Helsinki, Finland. Electronic address: merja.roivainen@thl.fi. 7. University of Helsinki, Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, PO Box 64, FI-00014 Helsinki, Finland. Electronic address: riitta.korpela@helsinki.fi. 8. Department of Otorhinolaryngology, Helsinki University Central Hospital and University of Helsinki, PO Box 220, FI-00290 Helsinki, Finland. Electronic address: anne.pitkaranta@helsinki.fi.
Abstract
OBJECTIVE:Probiotics may have potency in reducing upper respiratory infections, in particular in children. We studied findings from middle ear effusion (MEE) samples after randomized, placebo-controlled 3-week oral administration of probiotic Lactobacillus rhamnosus GG (L. GG) METHODS:40 children referred to tympanostomy were randomized to receive either L. GG or placebo (1:1) for 3 weeks before surgery. MEE samples were collected from 13 children (in total, 25 samples, 19 from the L. GG group and 6 from the placebo group) and analyzed for L. GG and pathogenic bacterial and viral findings. RESULTS: L. GG was present in 5 of the 25 MEE samples (4 from the L. GG group). Haemophilus infuenzae was the most prominent pathogen in 12 samples (10 from the L. GG group). Rhinovirus was present in 12 samples (10 from the L. GG group) and enterovirus in 1 sample (L. GG group). CONCLUSIONS: L. GG was present in the middle ear of children suffering from otitis media with effusion, but did not reduce the presence of pathogenic bacteria or viruses.
RCT Entities:
OBJECTIVE: Probiotics may have potency in reducing upper respiratory infections, in particular in children. We studied findings from middle ear effusion (MEE) samples after randomized, placebo-controlled 3-week oral administration of probiotic Lactobacillus rhamnosus GG (L. GG) METHODS: 40 children referred to tympanostomy were randomized to receive either L. GG or placebo (1:1) for 3 weeks before surgery. MEE samples were collected from 13 children (in total, 25 samples, 19 from the L. GG group and 6 from the placebo group) and analyzed for L. GG and pathogenic bacterial and viral findings. RESULTS:L. GG was present in 5 of the 25 MEE samples (4 from the L. GG group). Haemophilus infuenzae was the most prominent pathogen in 12 samples (10 from the L. GG group). Rhinovirus was present in 12 samples (10 from the L. GG group) and enterovirus in 1 sample (L. GG group). CONCLUSIONS:L. GG was present in the middle ear of children suffering from otitis media with effusion, but did not reduce the presence of pathogenic bacteria or viruses.
Authors: Marianne F L van den Broek; Ilke De Boeck; Filip Kiekens; An Boudewyns; Olivier M Vanderveken; Sarah Lebeer Journal: Clin Microbiol Rev Date: 2019-07-03 Impact factor: 26.132