| Literature DB >> 25083863 |
Jessica Nouws1, Gerald S Shadel2.
Abstract
Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.Entities:
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Year: 2014 PMID： 25083863 DOI： 10.1016/j.cell.2014.07.010
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582