Reenu Malhotra1, Kevin Turner1, Amnon Sonnenberg2, Robert M Genta3. 1. Miraca Life Sciences Research Institute, Irving, Texas. 2. Portland VA Medical Center, Portland, Oregon; Oregon Health and Science University, Portland, Oregon. 3. Miraca Life Sciences Research Institute, Irving, Texas; University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas. Electronic address: robert.genta@utsouthwestern.edu.
Abstract
BACKGROUND & AIMS: It is unclear whether the reported low prevalence of inflammatory bowel disease (IBD) in Southern and Eastern Asia is real (caused by genetic or environmental factors) or spurious (because of differences in awareness of the condition among physicians or different interpretations of endoscopic and histologic features). We aimed to estimate the prevalence of IBD in patients of different ethnicities who underwent endoscopy in the United States, with ileocolonic biopsies evaluated by a single group of gastrointestinal pathologists. METHODS: We used a national pathology database to collect data on 1,027,977 subjects who underwent colonoscopy with ileocolonic biopsies from January 2008 through December 2013 throughout the United States; mucosal biopsy specimens were evaluated and reported by 1 group of 35 histopathologists. Patients were stratified into the following ancestries: Indian (persons with ancestry in the Indian subcontinent), East Asian (China, Korea, Japan, and Vietnam), Hispanic, Jewish, and Other. The prevalence of ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis was determined for each ethnic group. RESULTS: In the study population, 30,812 patients were diagnosed with IBD (20,308 with UC, 7706 with CD, and 2798 with indeterminate colitis). UC was more commonly associated with Indian and Jewish ethnicity and less commonly associated with East Asian and Hispanic ethnicity. Similar patterns also applied to CD and to all types of IBD analyzed jointly. Among Indian patients, 11.7% of those of Gujarati origins had IBD, compared with 7.9% of other Indians (odds ratio, 1.5; 95% confidence interval, 1.14-2.11). CONCLUSIONS: Patients of Indian origin living in the United States have a greater risk for all types of IBD than other American populations. East Asians and Hispanics have a lower risk, possibly similar to that of the populations still living in their original countries. These findings may have relevance to the practice of gastroenterology in countries where there are sizable portions of the population with roots in the Indian subcontinent.
BACKGROUND & AIMS: It is unclear whether the reported low prevalence of inflammatory bowel disease (IBD) in Southern and Eastern Asia is real (caused by genetic or environmental factors) or spurious (because of differences in awareness of the condition among physicians or different interpretations of endoscopic and histologic features). We aimed to estimate the prevalence of IBD in patients of different ethnicities who underwent endoscopy in the United States, with ileocolonic biopsies evaluated by a single group of gastrointestinal pathologists. METHODS: We used a national pathology database to collect data on 1,027,977 subjects who underwent colonoscopy with ileocolonic biopsies from January 2008 through December 2013 throughout the United States; mucosal biopsy specimens were evaluated and reported by 1 group of 35 histopathologists. Patients were stratified into the following ancestries: Indian (persons with ancestry in the Indian subcontinent), East Asian (China, Korea, Japan, and Vietnam), Hispanic, Jewish, and Other. The prevalence of ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis was determined for each ethnic group. RESULTS: In the study population, 30,812 patients were diagnosed with IBD (20,308 with UC, 7706 with CD, and 2798 with indeterminate colitis). UC was more commonly associated with Indian and Jewish ethnicity and less commonly associated with East Asian and Hispanic ethnicity. Similar patterns also applied to CD and to all types of IBD analyzed jointly. Among Indian patients, 11.7% of those of Gujarati origins had IBD, compared with 7.9% of other Indians (odds ratio, 1.5; 95% confidence interval, 1.14-2.11). CONCLUSIONS:Patients of Indian origin living in the United States have a greater risk for all types of IBD than other American populations. East Asians and Hispanics have a lower risk, possibly similar to that of the populations still living in their original countries. These findings may have relevance to the practice of gastroenterology in countries where there are sizable portions of the population with roots in the Indian subcontinent.
Authors: J Dhaliwal; M W Carroll; J C deBruyn; A Ricciuto; E I Benchimol; S Lawrence; M Sherlock; W El-Matary; H Brill; P Church; E Wine; N Carman; A Muise; H Huynh; D R Mack; T D Walters; A M Griffiths; K Jacobson Journal: J Crohns Colitis Date: 2022-02-23 Impact factor: 10.020
Authors: Akram Sarabi Asiabar; Hamid Asadzadeh Aghdaei; Samin Zamani; Saied Bokaie; Mohammad Reza Zali; Mohammad Mehdi Feizabadi Journal: Med J Islam Repub Iran Date: 2019-07-29
Authors: Bharati Kochar; Edward L Barnes; Hans H Herfarth; Christopher F Martin; Ashwin N Ananthakrishnan; Dermot McGovern; Millie Long; Robert S Sandler Journal: Inflamm Intest Dis Date: 2017-11-18