Literature DB >> 25082863

KLF1: when less is more.

Deepa Manwani1, James J Bieker2.   

Abstract

In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies. They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

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Year:  2014        PMID： 25082863      PMCID： PMC4118480          DOI： 10.1182/blood-2014-05-576967

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  10 in total

Review 1.  Genetic modifiers of sickle cell disease.

Authors:  Martin H Steinberg; Paola Sebastiani
Journal:  Am J Hematol       Date:  2012-05-28       Impact factor: 10.047

2.  Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.

Authors:  Belinda Giardine; Joseph Borg; Douglas R Higgs; Kenneth R Peterson; Sjaak Philipsen; Donna Maglott; Belinda K Singleton; David J Anstee; A Nazli Basak; Barnaby Clark; Flavia C Costa; Paula Faustino; Halyna Fedosyuk; Alex E Felice; Alain Francina; Renzo Galanello; Monica V E Gallivan; Marianthi Georgitsi; Richard J Gibbons; Piero C Giordano; Cornelis L Harteveld; James D Hoyer; Martin Jarvis; Philippe Joly; Emmanuel Kanavakis; Panagoula Kollia; Stephan Menzel; Webb Miller; Kamran Moradkhani; John Old; Adamantia Papachatzopoulou; Manoussos N Papadakis; Petros Papadopoulos; Sonja Pavlovic; Lucia Perseu; Milena Radmilovic; Cathy Riemer; Stefania Satta; Iris Schrijver; Maja Stojiljkovic; Swee Lay Thein; Jan Traeger-Synodinos; Ray Tully; Takahito Wada; John S Waye; Claudia Wiemann; Branka Zukic; David H K Chui; Henri Wajcman; Ross C Hardison; George P Patrinos
Journal:  Nat Genet       Date:  2011-03-20       Impact factor: 38.330

Review 3.  Genetic association studies in β-hemoglobinopathies.

Authors:  Swee Lay Thein
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2013

Review 4.  Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.

Authors:  Daniel E Bauer; Sophia C Kamran; Stuart H Orkin
Journal:  Blood       Date:  2012-08-17       Impact factor: 22.113

Review 5.  The multifunctional role of EKLF/KLF1 during erythropoiesis.

Authors:  Miroslawa Siatecka; James J Bieker
Journal:  Blood       Date:  2011-05-25       Impact factor: 22.113

Review 6.  Thalassaemia.

Authors:  Douglas R Higgs; James Douglas Engel; George Stamatoyannopoulos
Journal:  Lancet       Date:  2011-09-09       Impact factor: 79.321

7.  Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.

Authors:  Joseph Borg; Petros Papadopoulos; Marianthi Georgitsi; Laura Gutiérrez; Godfrey Grech; Pavlos Fanis; Marios Phylactides; Annemieke J M H Verkerk; Peter J van der Spek; Christian A Scerri; Wilhelmina Cassar; Ruth Galdies; Wilfred van Ijcken; Zeliha Ozgür; Nynke Gillemans; Jun Hou; Marisa Bugeja; Frank G Grosveld; Marieke von Lindern; Alex E Felice; George P Patrinos; Sjaak Philipsen
Journal:  Nat Genet       Date:  2010-08-01       Impact factor: 38.330

Review 8.  Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching.

Authors:  Michael R Tallack; Andrew C Perkins
Journal:  Curr Opin Hematol       Date:  2013-05       Impact factor: 3.284

9.  Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment.

Authors:  Felix Lohmann; James J Bieker
Journal:  Development       Date:  2008-04-30       Impact factor: 6.868

10.  KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia.

Authors:  Dun Liu; Xinhua Zhang; Lihua Yu; Ren Cai; Xiaoxia Ma; Chengguang Zheng; Yuqiu Zhou; Qiji Liu; Xiaofeng Wei; Li Lin; Tizhen Yan; Jiwei Huang; Narla Mohandas; Xiuli An; Xiangmin Xu
Journal:  Blood       Date:  2014-05-14       Impact factor: 22.113
  10 in total
  4 in total

1.  Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.

Authors:  Yan Dai; Jose Sangerman; Hong Yuan Luo; Suthat Fucharoen; David H K Chui; Douglas V Faller; Susan P Perrine
Journal:  Blood Cells Mol Dis       Date:  2015-10-27       Impact factor: 3.039

2.  Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.

Authors:  Betty S Pace; Susan Perrine; Biaoru Li; Levi Makala; Hongyan Xu; Mayuko Takezaki; Roman F Wolf; Amy Wang; Xin Xu; Junfeng Huang; Asaf Alimardanov; Gregory J Tawa; Jose Sangerman; Aidan Faller; Wei Zheng; London Toney; Sharie J Haugabook
Journal:  Blood Cells Mol Dis       Date:  2021-03-12       Impact factor: 2.372

3.  Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.

Authors:  Michael S Boosalis; Jose I Sangerman; Gary L White; Roman F Wolf; Ling Shen; Yan Dai; Emily White; Levi H Makala; Biaoru Li; Betty S Pace; Mehdi Nouraie; Douglas V Faller; Susan P Perrine
Journal:  PLoS One       Date:  2015-12-29       Impact factor: 3.240

4.  Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish.

Authors:  Bingshe Han; Juntao Luo; Penglei Jiang; Yan Li; Qiong Wang; Yajing Bai; Jing Chen; Jian Wang; Junfang Zhang
Journal:  Front Genet       Date:  2020-12-04       Impact factor: 4.599
  4 in total

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