OBJECTIVE: In this secondary analysis of results of the Clinical Outcomes in MEasurement-Based Treatment (COMET) trial, patient behaviors that might account for the differences observed in clinical outcomes were examined. METHODS:Patients (N=914) diagnosed as having major depressive disorder participated intelephone interviews either monthly for six months (intervention) or at three and six months (usual care) asking about antidepressant medication-taking, use of psychotherapy or counseling, and participation in depression support groups. Physicians (N=83) in the intervention arm received monthly feedback regarding their patients' depression severity. RESULTS:A total of 664 (73%) patients completed the month 6 interview. The adjusted odds of current antidepressant use at six months were 85% greater (p=.01) for patients in the intervention (N=380) versus usual care (N=284) arms, according to multivariate regression analyses. CONCLUSIONS: More frequent measurement of depression symptoms was associated with greater medication persistence, which in turn may have mediated clinical improvements.
RCT Entities:
OBJECTIVE: In this secondary analysis of results of the Clinical Outcomes in MEasurement-Based Treatment (COMET) trial, patient behaviors that might account for the differences observed in clinical outcomes were examined. METHODS:Patients (N=914) diagnosed as having major depressive disorder participated in telephone interviews either monthly for six months (intervention) or at three and six months (usual care) asking about antidepressant medication-taking, use of psychotherapy or counseling, and participation in depression support groups. Physicians (N=83) in the intervention arm received monthly feedback regarding their patients' depression severity. RESULTS: A total of 664 (73%) patients completed the month 6 interview. The adjusted odds of current antidepressant use at six months were 85% greater (p=.01) for patients in the intervention (N=380) versus usual care (N=284) arms, according to multivariate regression analyses. CONCLUSIONS: More frequent measurement of depression symptoms was associated with greater medication persistence, which in turn may have mediated clinical improvements.
Authors: Tony Kendrick; Magdy El-Gohary; Beth Stuart; Simon Gilbody; Rachel Churchill; Laura Aiken; Abhishek Bhattacharya; Amy Gimson; Anna L Brütt; Kim de Jong; Michael Moore Journal: Cochrane Database Syst Rev Date: 2016-07-13
Authors: Jackson M Steinkamp; Nathaniel Goldblatt; Jacob T Borodovsky; Amy LaVertu; Ian M Kronish; Lisa A Marsch; Zev Schuman-Olivier Journal: JMIR Ment Health Date: 2019-03-12
Authors: Beatriz González de León; Tasmania Del Pino-Sedeño; Pedro Serrano-Pérez; Cristobalina Rodríguez Álvarez; Daniel Bejarano-Quisoboni; María M Trujillo-Martín Journal: BMC Psychiatry Date: 2022-07-20 Impact factor: 4.144