Literature DB >> 2508089

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

J C Shepherd1, U Walldorf, P Hug, W J Gehring.   

Abstract

In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

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Year:  1989        PMID： 2508089      PMCID： PMC298096          DOI： 10.1073/pnas.86.19.7520

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Changes in activity and amount of active elongation factor 1 alpha in aging and immortal human fibroblast cultures.

Authors:  J Cavallius; S I Rattan; B F Clark
Journal:  Exp Gerontol       Date:  1986       Impact factor: 4.032

2.  Molecular mapping of the rosy locus in Drosophila melanogaster.

Authors:  B Coté; W Bender; D Curtis; A Chovnick
Journal:  Genetics       Date:  1986-04       Impact factor: 4.562

3.  Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster.

Authors:  G C Webster; S L Webster
Journal:  Mech Ageing Dev       Date:  1984-03       Impact factor: 5.432

4.  Analysis of P transposable element functions in Drosophila.

Authors:  R E Karess; G M Rubin
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

Review 5.  Protein synthesis and degradation during aging and senescence.

Authors:  S C Makrides
Journal:  Biol Rev Camb Philos Soc       Date:  1983-08

6.  Genetic transformation of Drosophila with transposable element vectors.

Authors:  G M Rubin; A C Spradling
Journal:  Science       Date:  1982-10-22       Impact factor: 47.728

7.  Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster.

Authors:  G C Webster; S L Webster
Journal:  Mech Ageing Dev       Date:  1983-06       Impact factor: 5.432

8.  Two genes encode related cytoplasmic elongation factors 1 alpha (EF-1 alpha) in Drosophila melanogaster with continuous and stage specific expression.

Authors:  B Hovemann; S Richter; U Walldorf; C Cziepluch
Journal:  Nucleic Acids Res       Date:  1988-04-25       Impact factor: 16.971

9.  Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia.

Authors:  S Schneuwly; R Klemenz; W J Gehring
Journal:  Nature       Date:  1987 Feb 26-Mar 4       Impact factor: 49.962

10.  Expression of the Drosophila white gene under the control of the hsp70 heat shock promoter.

Authors:  H Steller; V Pirrotta
Journal:  EMBO J       Date:  1985-12-30       Impact factor: 11.598
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  30 in total

1.  eEF1A Controls ascospore differentiation through elevated accuracy, but controls longevity and fruiting body formation through another mechanism in Podospora anserina.

Authors:  P Silar; H Lalucque; V Haedens; D Zickler; M Picard
Journal:  Genetics       Date:  2001-08       Impact factor: 4.562

Review 2.  Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis.

Authors:  Sarah Thornton; Nisha Anand; Dan Purcell; Jonathan Lee
Journal:  J Mol Med (Berl)       Date:  2003-08-01       Impact factor: 4.599

3.  Multiple-stress analysis for isolation of Drosophila longevity genes.

Authors:  Horng-Dar Wang; Parsa Kazemi-Esfarjani; Seymour Benzer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-12       Impact factor: 11.205

4.  Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis.

Authors:  Pius Joseph; Yi-Xiong Lei; Tong-man Ong
Journal:  Mol Cell Biochem       Date:  2004-01       Impact factor: 3.396

5.  Nucleotide sequence of rabbit elongation factor 1 alpha cDNA.

Authors:  J Cavallius; W C Merrick
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

Review 6.  Mechanism and regulation of eukaryotic protein synthesis.

Authors:  W C Merrick
Journal:  Microbiol Rev       Date:  1992-06

7.  Developmental analysis of elongation factor-1 alpha expression in transgenic tobacco.

Authors:  V M Ursin; J M Irvine; W R Hiatt; C K Shewmaker
Journal:  Plant Cell       Date:  1991-06       Impact factor: 11.277

8.  Biphasic Stimulation of Translational Activity Correlates with Induction of Translation Elongation Factor 1 Subunit [alpha] upon Wounding in Potato Tubers.

Authors:  J. K. Morelli; C. K. Shewmaker; M. E. Vayda
Journal:  Plant Physiol       Date:  1994-11       Impact factor: 8.340

9.  Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display.

Authors:  R Shen; Z Z Su; C A Olsson; P B Fisher
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

10.  Cis and trans-acting elements involved in the activation of Arabidopsis thaliana A1 gene encoding the translation elongation factor EF-1 alpha.

Authors:  C Curie; T Liboz; C Bardet; E Gander; C Médale; M Axelos; B Lescure
Journal:  Nucleic Acids Res       Date:  1991-03-25       Impact factor: 16.971
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