Friedrich W Mohr1, David Holzhey2, Helge Möllmann3, Andreas Beckmann4, Christof Veit5, Hans Reiner Figulla6, Jochen Cremer7, Karl-Heinz Kuck8, Rüdiger Lange9, Ralf Zahn10, Stefan Sack11, Gerhard Schuler2, Thomas Walther12, Friedhelm Beyersdorf13, Michael Böhm14, Gerd Heusch15, Anne-Kathrin Funkat2, Thomas Meinertz16, Till Neumann17, Konstantinos Papoutsis18, Steffen Schneider19, Armin Welz20, Christian W Hamm3. 1. Heart Center Leipzig, Leipzig, Germany mohrf@medizin.uni-leipzig.de friedrich.mohr@herzzentrum-leipzig.de. 2. Heart Center Leipzig, Leipzig, Germany. 3. Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany. 4. Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie, Langenbeck-Virchow-Haus, Berlin, Germany. 5. BQS Institute for Quality and Patient Safety, Düsseldorf, Germany. 6. Division of Cardiology, 1st Department of Medicine, University Hospital of Jena, Jena, Germany. 7. Department of Cardiovascular Surgery, University of Schleswig-Holstein, Kiel, Germany. 8. Asklepios Klinik St. Georg, Hamburg, Germany. 9. German Heart Center Munich, Department of Cardiovascular Surgery, Technische Universität München, Munich, Germany. 10. Department of Cardiology, Medizinische Klinik B, Herzzentrum am Klinikum Ludwigshafen, Ludwigshafen, Germany. 11. Klinik für Kardiologie, Pneumologie und Internistische Intensivmedizin, Klinikum Schwabing, Munich, Germany. 12. Kerckhoff-Herzzentrum, Abteilung für Herzchirurgie, Bad Nauheim, Germany. 13. Universitätsklinikum Freiburg, Chirurgische Klinik Abteilung Herz- und Gefäßchirurgie, Freiburg, Germany. 14. Medizinische Klinik und Poliklinik, Universitätsklinik des Saarlandes, Innere Medizin III, Homburg/Saar, Germany. 15. Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany. 16. Deutsche Herzstiftung, Frankfurt am Main, Germany. 17. Department of Cardiology, University of Duisburg-Essen Medical School, Essen, Germany. 18. German Cardiac Society, Düsseldorf, Germany. 19. Institut für Herzinfarktforschung, Ludwigshafen, Germany. 20. Department of Cardiac Surgery, University of Bonn, Bonn, Germany.
Abstract
OBJECTIVES: The German Aortic Valve Registry (GARY) seeks to provide information on a real-world, all-comers basis for patients undergoing aortic valve interventions. This registry comprises patients undergoing the complete spectrum of transcutaneous and conventional surgical aortic valve interventions. The aim of this study was to use the GARY registry to evaluate conventional and catheter-based aortic valve interventions in several risk groups. METHODS: A total of 13 860 consecutive patients undergoing intervention for aortic valve disease [conventional aortic valve replacement (AVR) or transvascular/transapical TAVR (TV-/TA-TAVR)] were enrolled in 78 German centres in 2011. Baseline, procedural and outcome data, including quality of life, were acquired up to 1 year post-intervention. Vital status at 1 year was known for 98.1% of patients. RESULTS: The 1-year mortality rate was 6.7% for conventional AVR patients (n = 6523) and 11.0% for patients who underwent AVR with coronary artery bypass grafting (n = 3464). The 1-year mortality rate was 20.7 and 28.0% in TV- and TA-TAVR patients, respectively (n = 2695 and 1181). However, if patients were stratified into four risk groups by means of the EuroSCORE and the German AV Score, the highest risk cohorts showed the same mortality at 1 year with either therapy. More than 80% of patients in all groups were in the same or better state of health at 1 year post-intervention and were satisfied with the procedural outcome. CONCLUSIONS: Conventional AVR surgery yields excellent results after 1 year in lower-risk patients. Catheter-based AVR is a good alternative in high-risk and elderly patients.
OBJECTIVES: The German Aortic Valve Registry (GARY) seeks to provide information on a real-world, all-comers basis for patients undergoing aortic valve interventions. This registry comprises patients undergoing the complete spectrum of transcutaneous and conventional surgical aortic valve interventions. The aim of this study was to use the GARY registry to evaluate conventional and catheter-based aortic valve interventions in several risk groups. METHODS: A total of 13 860 consecutive patients undergoing intervention for aortic valve disease [conventional aortic valve replacement (AVR) or transvascular/transapical TAVR (TV-/TA-TAVR)] were enrolled in 78 German centres in 2011. Baseline, procedural and outcome data, including quality of life, were acquired up to 1 year post-intervention. Vital status at 1 year was known for 98.1% of patients. RESULTS: The 1-year mortality rate was 6.7% for conventional AVR patients (n = 6523) and 11.0% for patients who underwent AVR with coronary artery bypass grafting (n = 3464). The 1-year mortality rate was 20.7 and 28.0% in TV- and TA-TAVR patients, respectively (n = 2695 and 1181). However, if patients were stratified into four risk groups by means of the EuroSCORE and the German AV Score, the highest risk cohorts showed the same mortality at 1 year with either therapy. More than 80% of patients in all groups were in the same or better state of health at 1 year post-intervention and were satisfied with the procedural outcome. CONCLUSIONS: Conventional AVR surgery yields excellent results after 1 year in lower-risk patients. Catheter-based AVR is a good alternative in high-risk and elderly patients.
Authors: Luise Gaede; Johannes Blumenstein; Christoph Liebetrau; Oliver Dörr; Won-Keun Kim; Holger Nef; Oliver Husser; Jan Gülker; Albrecht Elsässer; Christian W Hamm; Stephan Achenbach; Helge Möllmann Journal: Clin Res Cardiol Date: 2019-06-24 Impact factor: 5.460
Authors: Richard Tanner; Barbara Moran; Ronan Margey; Gavin Blake; Catherine McGorrian; Jacqueline Geraghty; Susan Groarke; Jana Boleckova; John Hurley; Andrew Roy; David Barton; Declan Sugrue; Ivan P Casserly Journal: Ir J Med Sci Date: 2019-06-13 Impact factor: 1.568
Authors: Nicholas Chew; Jimmy Kim Fatt Hon; Wei Luen James Yip; Siew Pang Chan; Kian-Keong Poh; William Kok-Fai Kong; Kristine Leok Kheng Teoh; Tiong Cheng Yeo; Huay Cheem Tan; Edgar Lik Wui Tay Journal: Singapore Med J Date: 2016-08-12 Impact factor: 1.858
Authors: Gloria Färber; Sabine Bleiziffer; Torsten Doenst; Dimitra Bon; Andreas Böning; Helge Weiler; Eva Herrmann; Christian Frerker; Andreas Beckmann; Helge Möllmann; Stephan Ensminger; Raffi Bekeredjian; Thomas Walther; Wolfgang Harringer; Hugo A Katus; Christian W Hamm; Friedhelm Beyersdorf; Timm Bauer; Stephan Fichtlscherer Journal: Clin Res Cardiol Date: 2020-09-23 Impact factor: 5.460
Authors: Luise Gaede; Won-Keun Kim; Christoph Liebetrau; Oliver Dörr; Johannes Sperzel; Johannes Blumenstein; Alexander Berkowitsch; Thomas Walther; Christian Hamm; Albrecht Elsässer; Holger Nef; Helge Möllmann Journal: Clin Res Cardiol Date: 2017-09-29 Impact factor: 5.460