BACKGROUND: Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity. OBJECTIVE: This study aimed to evaluate the association between statin use and Bell's palsy using a population-based health insurance database. METHODS: This case-control study identified 1,977 subjects with Bell's palsy as cases and 5,931 sex- and age-matched subjects without Bell's palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell's palsy were further analyzed. RESULTS: By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4%, p < 0.001). Conditional logistic regression analysis revealed that after adjusting for diabetes mellitus, hypertension, and hyperlipidemia, the OR for prior statin use was 1.47 (95% CI 1.28-1.69) for cases compared with controls. Bell's palsy was significantly associated with previous regular statin use (≥60 days within 6 months) (adjusted OR: 1.46, 95% CI 1.28-1.67). However, there was no increased adjusted OR of irregular statin use (<60 days within 6 months) for cases compared with controls (OR: 1.09, 95% CI 0.82-1.46). CONCLUSIONS: Our present data suggest a potential association between regular statin use and Bell's palsy.
BACKGROUND: Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity. OBJECTIVE: This study aimed to evaluate the association between statin use and Bell's palsy using a population-based health insurance database. METHODS: This case-control study identified 1,977 subjects with Bell's palsy as cases and 5,931 sex- and age-matched subjects without Bell's palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell's palsy were further analyzed. RESULTS: By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4%, p < 0.001). Conditional logistic regression analysis revealed that after adjusting for diabetes mellitus, hypertension, and hyperlipidemia, the OR for prior statin use was 1.47 (95% CI 1.28-1.69) for cases compared with controls. Bell's palsy was significantly associated with previous regular statin use (≥60 days within 6 months) (adjusted OR: 1.46, 95% CI 1.28-1.67). However, there was no increased adjusted OR of irregular statin use (<60 days within 6 months) for cases compared with controls (OR: 1.09, 95% CI 0.82-1.46). CONCLUSIONS: Our present data suggest a potential association between regular statin use and Bell's palsy.
Authors: Veronique E Miron; Simone P Zehntner; Tanja Kuhlmann; Samuel K Ludwin; Trevor Owens; Timothy E Kennedy; Barry J Bedell; Jack P Antel Journal: Am J Pathol Date: 2009-04-06 Impact factor: 4.307
Authors: Matthew G Crowson; Hillary Mulder; Derek D Cyr; Alan W Langman; Walter T Lee; Kourosh Parham; Melissa A Pynnonen; Kristine Schulz; Jennifer J Shin; David Witsell; Andrea Vambutas Journal: Otol Neurotol Date: 2018-08 Impact factor: 2.311
Authors: So Young Kim; Jee Hye Wee; Chanyang Min; Dae-Myoung Yoo; Hyo Geun Choi Journal: Int J Environ Res Public Health Date: 2020-11-13 Impact factor: 3.390