Literature DB >> 25079019

Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?

Maurizio Gallieni1, Maria Fusaro2.   

Abstract

The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.

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Year:  2014        PMID： 25079019     DOI： 10.1038/ki.2014.24

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  6 in total

Review 1.  Vitamin K effects in human health: new insights beyond bone and cardiovascular health.

Authors:  Maria Fusaro; Maurizio Gallieni; Camillo Porta; Thomas L Nickolas; Pascale Khairallah
Journal:  J Nephrol       Date:  2019-12-19       Impact factor: 3.902

2.  A new LC-MS assay for the quantitative analysis of vitamin K metabolites in human urine.

Authors:  Matthew G McDonald; Catherine K Yeung; Aaron M Teitelbaum; Amanda L Johnson; Shinya Fujii; Hiroyuki Kagechika; Allan E Rettie
Journal:  J Lipid Res       Date:  2019-01-22       Impact factor: 5.922

Review 3.  Vitamin K and bone.

Authors:  Maria Fusaro; Maria Cristina Mereu; Andrea Aghi; Giorgio Iervasi; Maurizio Gallieni
Journal:  Clin Cases Miner Bone Metab       Date:  2017-10-25

Review 4.  The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification.

Authors:  Domitilla Mandatori; Letizia Pelusi; Valeria Schiavone; Caterina Pipino; Natalia Di Pietro; Assunta Pandolfi
Journal:  Nutrients       Date:  2021-04-07       Impact factor: 5.717

Review 5.  Vitamin K and Osteoporosis.

Authors:  Maria Fusaro; Giuseppe Cianciolo; Maria Luisa Brandi; Serge Ferrari; Thomas L Nickolas; Giovanni Tripepi; Mario Plebani; Martina Zaninotto; Giorgio Iervasi; Gaetano La Manna; Maurizio Gallieni; Roberto Vettor; Andrea Aghi; Lorenzo Gasperoni; Sandro Giannini; Stefania Sella; Angela M Cheung
Journal:  Nutrients       Date:  2020-11-25       Impact factor: 5.717

Review 6.  The Role of Vitamin K in CKD-MBD.

Authors:  Maria Fusaro; Francesco Tondolo; Lorenzo Gasperoni; Giovanni Tripepi; Mario Plebani; Martina Zaninotto; Thomas L Nickolas; Markus Ketteler; Andrea Aghi; Cristina Politi; Gaetano La Manna; Maria Luisa Brandi; Serge Ferrari; Maurizio Gallieni; Maria Cristina Mereu; Giuseppe Cianciolo
Journal:  Curr Osteoporos Rep       Date:  2022-02-08       Impact factor: 5.163
  6 in total

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