M Lappas1. 1. 1] Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia [2] Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Melbourne, VIC, Australia.
Abstract
OBJECTIVE: To determine the effect of pre-existing maternal obesity and gestational diabetes mellitus (GDM) on the circulating levels of insulin growth factor-binding protein (IGFBPs) in cord and maternal plasma. STUDY DESIGN: IGFBP-1-7 levels were measured on maternal and cord plasma from women with normal glucose tolerance (NGT) (30 non-obese and 36 obese) and GDM (44 non-obese and 26 obese) at the time of term elective cesarean section. RESULT: Maternal plasma IGFBP-1, IGFBP-6 and IGFBP-rP1 concentrations were significantly lower in NGT obese compared with NGT non-obese women and in non-obese GDM women compared with non-obese NGT women. In cord plasma, IGFBP-1-3 and IGFBP-rP1 concentrations were significantly lower in NGT obese compared with NGT non-obese women and in non-obese GDM women compared with non-obese NGT women. Significant positive correlations were observed between maternal and cord plasma IGFBP-1 and IGFBP-rP1 levels and maternal insulin resistance. In cord plasma, significant positive correlations were observed between IGFBP-1-3 and IGFBP-rP1 levels and fetal insulin resistance. Fetal birthweight was inversely correlated with maternal plasma IGFBP-1 levels and cord plasma IGFBP-1 and IGFBP-2 levels. When corrected for maternal body mass index, the only significant relationship that still existed was between cord plasma IGFBP-1 concentrations and fetal birthweight. CONCLUSION: At the time of term cesarean section, pre-existing maternal obesity and GDM are associated with lower IGFBP levels in maternal and cord plasma. Alterations in circulating IGF and IGFBPs may alter birthweight and/or neonatal adiposity. This may lead to alterations in optimal growth trajectory and lead to metabolic disorders later in life.
OBJECTIVE: To determine the effect of pre-existing maternal obesity and gestational diabetes mellitus (GDM) on the circulating levels of insulin growth factor-binding protein (IGFBPs) in cord and maternal plasma. STUDY DESIGN:IGFBP-1-7 levels were measured on maternal and cord plasma from women with normal glucose tolerance (NGT) (30 non-obese and 36 obese) and GDM (44 non-obese and 26 obese) at the time of term elective cesarean section. RESULT: Maternal plasma IGFBP-1, IGFBP-6 and IGFBP-rP1 concentrations were significantly lower in NGT obese compared with NGT non-obesewomen and in non-obese GDM women compared with non-obese NGT women. In cord plasma, IGFBP-1-3 and IGFBP-rP1 concentrations were significantly lower in NGT obese compared with NGT non-obesewomen and in non-obese GDM women compared with non-obese NGT women. Significant positive correlations were observed between maternal and cord plasma IGFBP-1 and IGFBP-rP1 levels and maternal insulin resistance. In cord plasma, significant positive correlations were observed between IGFBP-1-3 and IGFBP-rP1 levels and fetal insulin resistance. Fetal birthweight was inversely correlated with maternal plasma IGFBP-1 levels and cord plasma IGFBP-1 and IGFBP-2 levels. When corrected for maternal body mass index, the only significant relationship that still existed was between cord plasma IGFBP-1 concentrations and fetal birthweight. CONCLUSION: At the time of term cesarean section, pre-existing maternal obesity and GDM are associated with lower IGFBP levels in maternal and cord plasma. Alterations in circulating IGF and IGFBPs may alter birthweight and/or neonatal adiposity. This may lead to alterations in optimal growth trajectory and lead to metabolic disorders later in life.
Authors: A H Heald; J K Cruickshank; L K Riste; J E Cade; S Anderson; A Greenhalgh; J Sampayo; W Taylor; W Fraser; A White; J M Gibson Journal: Diabetologia Date: 2001-03 Impact factor: 10.122
Authors: Caroline A Crowther; Janet E Hiller; John R Moss; Andrew J McPhee; William S Jeffries; Jeffrey S Robinson Journal: N Engl J Med Date: 2005-06-12 Impact factor: 91.245
Authors: Robert S Lindsay; J A Westgate; J Beattie; N S Pattison; G Gamble; L F J Mildenhall; B H Breier; Frank D Johnstone Journal: Clin Endocrinol (Oxf) Date: 2007-03 Impact factor: 3.478
Authors: Valentina Evdokimova; Cristina E Tognon; Tania Benatar; Wenyi Yang; Konstantin Krutikov; Michael Pollak; Poul H B Sorensen; Arun Seth Journal: Sci Signal Date: 2012-12-18 Impact factor: 8.192
Authors: L C Giudice; F de Zegher; S E Gargosky; B A Dsupin; L de las Fuentes; R A Crystal; R L Hintz; R G Rosenfeld Journal: J Clin Endocrinol Metab Date: 1995-05 Impact factor: 5.958
Authors: D Abdulkhalikova; A Sustarsic; Eda Vrtačnik Bokal; N Jancar; M Jensterle; T Burnik Papler Journal: Front Endocrinol (Lausanne) Date: 2022-06-22 Impact factor: 6.055
Authors: Chad A Logan; Larissa Thiel; Rebecca Bornemann; Wolfgang Koenig; Frank Reister; Hermann Brenner; Dietrich Rothenbacher; Jon Genuneit Journal: PLoS One Date: 2016-02-22 Impact factor: 3.240
Authors: Mikael S Huhtala; Kristiina Tertti; Juuso Juhila; Timo Sorsa; Tapani Rönnemaa Journal: BMC Pregnancy Childbirth Date: 2020-07-11 Impact factor: 3.007