Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.

Literature DB >> 25078326

The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.

Ru Liu¹, Yaling Wang, Qing Yuan, Deyi An, Jingyuan Li, Xueyun Gao.

Abstract

Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 25078326 DOI： 10.1039/c4cc03320e

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

Keyword Cloud
Cited

9 in total

1. Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio.

Authors: Alexander P Klapproth; Jan Schuemann; Stefan Stangl; Tianwu Xie; Wei Bo Li; Gabriele Multhoff
Journal: Cancer Nanotechnol Date: 2021-10-24

2. Surface Functionalization of Organosilica Nanoparticles With Au Nanoparticles Inhibits Cell Proliferation and Induces Cell Death in 4T1 Mouse Mammary Tumor Cells for DNA and Mitochondrial-Synergized Damage in Radiotherapy.

Authors: Chihiro Mochizuki; Yukihito Kayabe; Junna Nakamura; Masaya Igase; Takuya Mizuno; Michihiro Nakamura
Journal: Front Chem Date: 2022-05-10 Impact factor: 5.545

Review 3. Biological mechanisms of gold nanoparticle radiosensitization.

Authors: Soraia Rosa; Chris Connolly; Giuseppe Schettino; Karl T Butterworth; Kevin M Prise
Journal: Cancer Nanotechnol Date: 2017-02-02

4. Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies.

Authors: Meiqing Liu; Liang Gao; Lina Zhao; Jian He; Qing Yuan; Peng Zhang; Yawei Zhao; Xueyun Gao
Journal: Sci Rep Date: 2017-03-09 Impact factor: 4.379

The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.

1. Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio.

2. Surface Functionalization of Organosilica Nanoparticles With Au Nanoparticles Inhibits Cell Proliferation and Induces Cell Death in 4T1 Mouse Mammary Tumor Cells for DNA and Mitochondrial-Synergized Damage in Radiotherapy.

Review 3. Biological mechanisms of gold nanoparticle radiosensitization.

4. Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies.

5. Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-κB Pathway.

Review 6. Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy.

Review 7. Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications.

8. Gold Clusters Attenuate Inflammation in Rat Mesangial Cells via Inhibiting the Activation of NF-κB Pathway.

9. Gold clusters prevent breast cancer bone metastasis by suppressing tumor-induced osteoclastogenesis.