Generic pixel-wise speckle detection in Fourier-domain optical coherence tomography images.

We present a generic phase-domain processing method for detecting speckles in Fourier-domain optical coherence tomography (OCT) images. The physics behind the interferometry is revisited and analytically along with simulation results it indicates that the speckle formation comes with phase distortion to the complex OCT signal. The first and the second derivatives of phase along the imaging depth are then calculated for speckle identification. The phase-domain processing method was applied to images acquired by both spectral-domain OCT and swept-source OCT systems, and the experimental results show that this method enables pixel-wise speckle identification.