Francesco Sopracordevole1, Giuseppe Chiossi2, Maggiorino Barbero3, Paolo Cristoforoni4, Bruno Ghiringhello5, Antonio Frega6, Francesca Tortolani2, Fausto Boselli2, Nicolò Clemente7, Andrea Ciavattini8. 1. Department of Gynecological Oncology, Centro di Riferimento Oncologico, Aviano, Italy. 2. Department of Gynaecological, Obstetric and Pediatric Sciences, Section of Gynaecology, University of Modena and Reggio Emilia, Modena, Italy. 3. Department of Obstetrics and Gynecology, Asti Community Hospital, Asti, Italy. 4. Department of Obstetrics and Gynecology, University of Genoa, Genoa, Italy. 5. Department of Pathology, University of Turin, Turin, Italy. 6. 2nd Clinic of Obstetrics and Gynaecology, University "La Sapienza", Rome, Italy. 7. Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy. 8. Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy ciavattini.a@libero.it.
Abstract
AIM: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). PATIENTS AND METHODS: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). RESULTS: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5 ± 20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. CONCLUSION: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women. Copyright
AIM: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). PATIENTS AND METHODS: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). RESULTS: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5 ± 20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. CONCLUSION: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women. Copyright
Authors: Silvana Pedra Nobre; Varvara Mazina; Alexia Iasonos; Qin C Zhou; Yukio Sonoda; Ginger Gardner; Kara Long-Roche; Mario M Leitao; Nadeem R Abu-Rustum; Jennifer J Mueller Journal: Int J Gynecol Cancer Date: 2020-06-03 Impact factor: 3.437
Authors: Jill H Tseng; Alessia Aloisi; Yukio Sonoda; Ginger J Gardner; Oliver Zivanovic; Nadeem R Abu-Rustum; Mario M Leitao Journal: Int J Gynecol Cancer Date: 2018-09 Impact factor: 3.437