Shyamal Patel1, Waleed F Mourad2, Chengtao Wang3, Bhaswant Dhanireddy4, Catherine Concert4, Magdalena Ryniak4, Azita S Khorsandi5, Rania A Shourbaji4, Zujun Li6, Bruce Culliney6, Rajal Patel4, Richard L Bakst4, Theresa Tran7, Daniel Shasha4, Stimson Schantz7, Mark S Persky7, Kenneth S Hu4, Louis B Harrison4. 1. Department of Radiation Oncology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A. Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY, U.S.A. 2. Department of Radiation Oncology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A. Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY, U.S.A. Waleed246@gmail.com. 3. Department of Radiation Oncology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A. Department of Radiation Oncology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 4. Department of Radiation Oncology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A. 5. Department of Radiology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A. 6. Department of Medical Oncology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A. 7. Department of Otolaryngology, Mount Sinai Beth Israel Medical Center, New York, NY, U.S.A.
Abstract
AIM: To evaluate the locoregional control and treatment toxicity of patients with pleomorphic adenoma after resection with close or positive margins followed by postoperative radiation therapy (PORT). PATIENTS AND METHODS: Between 2002 and 2011, twenty-one patients underwent PORT at the Mount Sinai Beth Israel Medical Center for pleomorphic adenoma of the parotid with close or positive margins. Four out of the 21 patients (19%) had recurrent lesions. The median dose was 57.6 Gy (range 55.8-69.96) delivered at 1.8-2.12 Gy/fraction. Treatment and follow-up data were retrospectively analyzed for locoregional control as well as acute- and late-treatment toxicities. Actuarial survival analysis was also performed. RESULTS: Twelve women and 9 men with a median age of 46 (26-65) at PORT were included in this study. Eighty-one percent of the cohort had positive resection margins while 19% had close margins. At a median follow-up of 92 months, 19/21 patients (90%) had locoregional control. Two patients who failed had primary lesions which recurred locally, and initially had positive margins. The two recurrences occurred at 8 months and 12 months. Acute Radiation Therapy Oncology Group (RTOG) grade 1 and 2 toxicities were experienced by 11 (52%) and 4 (19%) patients, respectively, while 2 (10%) experienced late RTOG grade 1 toxicities. No patients experienced any grade 2-4 late toxicities. Actuarial survival was 100%. CONCLUSION: PORT for patients with pleomorphic adenoma of the parotid gland after resection with close or positive margins results in excellent locoregional control and low treatment-related morbidity. Copyright
AIM: To evaluate the locoregional control and treatment toxicity of patients with pleomorphic adenoma after resection with close or positive margins followed by postoperative radiation therapy (PORT). PATIENTS AND METHODS: Between 2002 and 2011, twenty-one patients underwent PORT at the Mount Sinai Beth Israel Medical Center for pleomorphic adenoma of the parotid with close or positive margins. Four out of the 21 patients (19%) had recurrent lesions. The median dose was 57.6 Gy (range 55.8-69.96) delivered at 1.8-2.12 Gy/fraction. Treatment and follow-up data were retrospectively analyzed for locoregional control as well as acute- and late-treatment toxicities. Actuarial survival analysis was also performed. RESULTS: Twelve women and 9 men with a median age of 46 (26-65) at PORT were included in this study. Eighty-one percent of the cohort had positive resection margins while 19% had close margins. At a median follow-up of 92 months, 19/21 patients (90%) had locoregional control. Two patients who failed had primary lesions which recurred locally, and initially had positive margins. The two recurrences occurred at 8 months and 12 months. Acute Radiation Therapy Oncology Group (RTOG) grade 1 and 2 toxicities were experienced by 11 (52%) and 4 (19%) patients, respectively, while 2 (10%) experienced late RTOG grade 1 toxicities. No patients experienced any grade 2-4 late toxicities. Actuarial survival was 100%. CONCLUSION: PORT for patients with pleomorphic adenoma of the parotid gland after resection with close or positive margins results in excellent locoregional control and low treatment-related morbidity. Copyright
Authors: Bayan Alzumaili; Bin Xu; Maelle Saliba; Abderhman Abuhashem; Ian Ganly; Ronald Ghossein; Nora Katabi Journal: Am J Surg Pathol Date: 2021-11-15 Impact factor: 6.298
Authors: Sarah E Nicholas; Wei Fu; Angela L Liang; Regina DeLuna; Luka Vujaskovic; Justin Bishop; Brandi R Page; Harry Quon; Christine Gourin; Carole Fakhry; David Eisele; Ana P Kiess Journal: Adv Radiat Oncol Date: 2021-03-02