Abdulkader Albasri1, Wakkas Fadhil2, John H Scholefield3, Lindy G Durrant4, Mohammad Ilyas5. 1. Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, U.K. Division of Pathology, Faculty of Medicine, University of Tibah, Medina, Saudi Arabia. 2. Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, U.K. 3. Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, U.K. 4. Academic Department of Clinical Oncology, School of Molecular Medical Sciences, City Hospital Campus, University of Nottingham, Nottingham, U.K. 5. Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, U.K. Mohammad.ilyas@nottingham.ac.uk.
Abstract
AIM: To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. MATERIALS AND METHODS: P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on a tissue microarray. P-FAK and TNS4 expression were assessed by immunohistochemistry in 40 cases of paired primary colorectal cancer and corresponding hepatic metastases. RESULTS: Nuclear P-FAK expression was observed in 44% of studied cases. Positive nuclear P-FAK expression was associated with shorter disease-specific survival in univariate (p=0.005) and multivariate analysis (p=0.016). P-FAK expression was greater in metastases than the primary tumours (p<0.001) and showed significant association with nuclear TNS4 (p<0.001) in metastases. CONCLUSION: P-FAK expression is an independent prognostic marker in CRC. The present data suggest that the FAK signalling pathway may interact with TNS4, a known oncogene in CRC. Copyright
AIM: To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. MATERIALS AND METHODS: P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on a tissue microarray. P-FAK and TNS4 expression were assessed by immunohistochemistry in 40 cases of paired primary colorectal cancer and corresponding hepatic metastases. RESULTS: Nuclear P-FAK expression was observed in 44% of studied cases. Positive nuclear P-FAK expression was associated with shorter disease-specific survival in univariate (p=0.005) and multivariate analysis (p=0.016). P-FAK expression was greater in metastases than the primary tumours (p<0.001) and showed significant association with nuclear TNS4 (p<0.001) in metastases. CONCLUSION: P-FAK expression is an independent prognostic marker in CRC. The present data suggest that the FAK signalling pathway may interact with TNS4, a known oncogene in CRC. Copyright
Authors: Lik Hang Lee; Lindy Davis; Lourdes Ylagan; Angela R Omilian; Kristopher Attwood; Canan Firat; Jinru Shia; Philip B Paty; William G Cance Journal: J Natl Cancer Inst Date: 2022-05-09 Impact factor: 11.816
Authors: Alan Serrels; Tom Lund; Bryan Serrels; Adam Byron; Rhoanne C McPherson; Alexander von Kriegsheim; Laura Gómez-Cuadrado; Marta Canel; Morwenna Muir; Jennifer E Ring; Eleni Maniati; Andrew H Sims; Jonathan A Pachter; Valerie G Brunton; Nick Gilbert; Stephen M Anderton; Robert J B Nibbs; Margaret C Frame Journal: Cell Date: 2015-09-24 Impact factor: 41.582
Authors: Isabelle Tancioni; Nichol L G Miller; Sean Uryu; Christine Lawson; Christine Jean; Xiao Lei Chen; Elizabeth G Kleinschmidt; David D Schlaepfer Journal: Breast Cancer Res Date: 2015-03-28 Impact factor: 6.466