Keisuke Ikeda1, Eiji Oki2, Hiroshi Saeki1, Koji Ando1, Masaru Morita1, Yoshinao Oda3, Masakazu Imamura1, Yoshihiro Kakeji1, Yoshihiko Maehara1. 1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan okieiji@surg2.med.kyushu-u.ac.jp. 3. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Abstract
AIM: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various human cancer tissues. MATERIALS AND METHODS: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. RESULTS: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). CONCLUSION: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value. Copyright
AIM: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various humancancer tissues. MATERIALS AND METHODS: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. RESULTS: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). CONCLUSION: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value. Copyright
Authors: Yarely M Salinas-Vera; Dolores Gallardo-Rincón; Raúl García-Vázquez; Olga N Hernández-de la Cruz; Laurence A Marchat; Juan Antonio González-Barrios; Erika Ruíz-García; Carlos Vázquez-Calzada; Estefanía Contreras-Sanzón; Martha Resendiz-Hernández; Horacio Astudillo-de la Vega; José L Cruz-Colin; Alma D Campos-Parra; César López-Camarillo Journal: Front Oncol Date: 2019-05-14 Impact factor: 6.244