| Literature DB >> 2507484 |
Y Shirakata1, M Kawada, Y Fujiki, H Sano, M Oda, K Yaginuma, M Kobayashi, K Koike.
Abstract
To examine the transforming potential of the X gene product of hepatitis B virus (HBV), the X-gene-containing region (referred to as the HBx region) was introduced into mouse NIH3T3 cells. Each transformed cell line expressed X-coding mRNA at a different level. A positive correlation was found between the level of X-coding mRNA and the saturation density of the cells. The HBx-transformed cell lines exhibited X protein production and tumor formation in nude mice. The function of HBV in oncogenesis may involve the continuous expression of the X-gene-coded product in the HBV DNA-integrated cells.Entities:
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Year: 1989 PMID： 2507484 PMCID： PMC5917810 DOI： 10.1111/j.1349-7006.1989.tb01686.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050