Literature DB >> 25074815

Phytochemical analysis and antileukemic activity of polyphenolic constituents of Toona sinensis.

Akinori Kakumu1, Masayuki Ninomiya2, Mai Efdi3, Morina Adfa4, Masahiro Hayashi5, Kaori Tanaka6, Mamoru Koketsu7.   

Abstract

Toona sinensis is a traditional Chinese medicine belonging to the Meliaceae family. The aim of this study was to identify the potential compounds responsible for anticancer activity of T. sinensis. The EtOAc extracts of leaves and woods of T. sinensis inhibited cell proliferation and induced apoptosis in human leukemia HL-60 cells. Our phytochemical research of these extracts led to the isolation of various polyphenolic constituents. The chemical structures were determined by spectroscopic analyses. Among isolates, gallic acid and loropetalin D showed inhibition of cell proliferation and possible induction of apoptosis in these cells. Overall, our results revealed the importance of T. sinensis as a chemopreventive medicinal plant. In addition, an analysis of structure-activity relationship indicated that the number of galloyl groups affects their antileukemic potency.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antileukemic activity; Degree of galloylation; Gallic acid; Loropetalin D; Toona sinensis

Mesh：

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Year:  2014        PMID： 25074815     DOI： 10.1016/j.bmcl.2014.07.022

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease.

Authors:  Wenxin Zhuang; Meiyun Cai; Wanzhong Li; Chao Chen; Yanqiang Wang; E Lv; Wenyu Fu
Journal:  Neurochem Res       Date:  2020-06-17       Impact factor: 3.996

2.  Quantitative Analysis and Comparison of Four Major Flavonol Glycosides in the Leaves of Toona sinensis (A. Juss.) Roemer (Chinese Toon) from Various Origins by High-Performance Liquid Chromatography-Diode Array Detector and Hierarchical Clustering Analysis.

Authors:  Xiaoxiang Sun; Liting Zhang; Yaqi Cao; Qinying Gu; Huan Yang; James P Tam
Journal:  Pharmacogn Mag       Date:  2016-05-11       Impact factor: 1.085

3.  Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis via enhancement of oxidative stress in human colorectal cancer SW620 cells.

Authors:  Yali Zhang; Yucheng Guo; Mimi Wang; Huanhuan Dong; Jingfang Zhang; Liyu Zhang
Journal:  Oncol Rep       Date:  2017-10-17       Impact factor: 3.906

4.  The Leaf Extracts of Toona sinensis and Fermented Culture Broths of Antrodia camphorata Synergistically Cause Apoptotic Cell Death in Promyelocytic Leukemia Cells.

Authors:  Hsin-Ling Yang; Ya-Ting Kuo; Yugandhar Vudhya Gowrisankar; Kai-Yuan Lin; Li-Sung Hsu; Pei-Jane Huang; Hui-Chang Lin; You-Cheng Hseu
Journal:  Integr Cancer Ther       Date:  2020 Jan-Dec       Impact factor: 3.279

Review 5.  Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.

Authors:  Shaden A M Khalifa; Nermeen Yosri; Mohamed F El-Mallah; Reem Ghonaim; Zhiming Guo; Syed Ghulam Musharraf; Ming Du; Alfi Khatib; Jianbo Xiao; Aamer Saeed; Haged H R El-Seedi; Chao Zhao; Thomas Efferth; Hesham R El-Seedi
Journal:  Phytomedicine       Date:  2020-08-29       Impact factor: 5.340

6.  Lactam Triterpenoids from the Bark of Toona sinensis.

Authors:  Qian-Qian Meng; Xing-Rong Peng; Shuang-Yang Lu; Luo-Sheng Wan; Xia Wang; Jin-Run Dong; Rui Chu; Lin Zhou; Xiao-Nian Li; Ming-Hua Qiu
Journal:  Nat Prod Bioprospect       Date:  2016-10-18

Review 7.  Ethnopharmacology, phytochemistry, biological activities, and therapeutic applications of Cedrela serrata Royle: A mini review.

Authors:  Hanine Almubayedh; Rizwan Ahmad
Journal:  J Ethnopharmacol       Date:  2019-09-05       Impact factor: 4.360
  7 in total

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