Genetic association of BSF2 polymorphism and susceptibility to lung cancer.

BSF2 polymorphism is believed to affect the transcriptional capability of the gene. Studies of lung cancer have associated BSF2 polymorphism with risk of lung cancer, only failing to identify whether this polymorphism predisposes an individual variation in the susceptibility to the malignant cancer. The primary aim of this study was to determine the association. An exhaustive literature search was conducted in the Medline and CNKI databases. Based on the data extracted from each of the included studies, we estimated the risk of lung cancer ascribed to BSF2 polymorphism by calculating ORs and its 95 % CIs. When pooling all eligible studies into the meta-analysis, we did not see any evidence suggesting there was a significant association between BSF2 polymorphism and risk of lung cancer. For the studies of Caucasian sample, the effects were exactly the same as those observed in the overall comparison. Our results suggest that BSF2 polymorphism may not predispose genetic susceptibility toward lung cancer in Caucasian populations, which nevertheless requires additional investigation.