Literature DB >> 2507305

Serum bilirubin levels with antiepileptic drugs.

H Gough1, T Goggin, M Crowley, N Callaghan.   

Abstract

The incidence of reduced bilirubin levels in 168 outpatients with epilepsy, compared with levels in 69 controls, has been investigated. Highly significant (p less than 0.001) reductions in average bilirubin levels were noted for carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and multiple drug groups. A marginally significant (p less than 0.05) reduction in bilirubin levels occurred in patients treated with valproate (VPA) which, unlike the other drugs, has not been shown to induce hepatic enzymes.

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Year:  1989        PMID： 2507305     DOI： 10.1111/j.1528-1157.1989.tb05478.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  3 in total

1.  Accuracy of Valproic Acid Concentration Correction Based on Serum Albumin.

Authors:  Aulbrey Drisaldi; Erin Weeda; Ron Neyens; Nicholas Orvin; Leonardo Bonilha; Zeke Campbell; Nicole Bohm
Journal:  Neurocrit Care       Date:  2019-04       Impact factor: 3.210

2.  Identifying Potential Therapeutic Applications and Diagnostic Harms of Increased Bilirubin Concentrations: A Clinical and Genetic Approach.

Authors:  Jacy T Zanussi; Juan Zhao; Chad A Dorn; Ge Liu; QiPing Feng; WeiQi Wei; Jonathan D Mosley; C Michael Stein; Vivian K Kawai
Journal:  Clin Pharmacol Ther       Date:  2021-10-24       Impact factor: 6.903

3.  Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.

Authors:  Ingrid F Metzger; Troy C Quigg; Noam Epstein; Abdulateef O Aregbe; Nancy Thong; John T Callaghan; David A Flockhart; Anne T Nguyen; Colleen K Stevens; Samir K Gupta; Zeruesenay Desta
Journal:  Curr Ther Res Clin Exp       Date:  2014-09-27
  3 in total

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