Literature DB >> 25072695

Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide.

Hiroki Iwasaki1, Kenji Suzuki, Mitsunari Yamane, Shohei Yoshida, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita.   

Abstract

A novel method for indole skeleton synthesis under mild conditions mediated by samarium(ii) diiodide has been developed. The reaction of N-allenyl-2-iodoaniline derivatives with SmI2 in the presence of HMPA and i-PrOH at 0 °C afforded indole derivatives in high yields.

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Year:  2014        PMID: 25072695     DOI: 10.1039/c4ob01164c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  1 in total

1.  Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings.

Authors:  Hui Peng; Kai Jiang; Guangjin Zhen; Furong Wang; Biaolin Yin
Journal:  RSC Adv       Date:  2020-03-23       Impact factor: 3.361

  1 in total

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