Literature DB >> 25071001

Treatment outcomes for patients with multidrug-resistant tuberculosis in post-earthquake Port-au-Prince, Haiti.

Macarthur Charles1, Stalz Charles Vilbrun2, Serena P Koenig2, Lauren M Hashiguchi2, Marie Marcelle Mabou2, Oksana Ocheretina2, Jean W Pape2.   

Abstract

We report outcomes and 12-month survival for the first cohort of patients to undergo multidrug-resistant tuberculosis (MDR-TB) treatment after the earthquake in Haiti. From March 3, 2010 to March 28, 2013, 110 patients initiated treatment of laboratory-confirmed MDR-TB at the Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) Center in Port-au-Prince, Haiti. Twenty-seven patients (25%) were human immunodeficiency virus (HIV)-positive. As of October 31, 2013, 95 (86%) patients were either cured or alive on treatment, 4 (4%) patients defaulted, and 11 (10%) patients died. Culture conversion occurred by 30 days in 14 (13%) patients, 60 days in 49 (45%) patients, and 90 days in 81 (74%) patients. The probabilities of survival to 12 months were 96% (95% confidence interval [95% CI] = 89-99) and 85% (95% CI = 64-94) for HIV-negative and -positive patients, respectively. Despite adverse conditions, outcomes for patients with MDR-TB are highly encouraging. Major efforts are underway to scale up community directly observed therapy and expand care to other regions of Haiti. © The American Society of Tropical Medicine and Hygiene.

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Year:  2014        PMID: 25071001      PMCID: PMC4183393          DOI: 10.4269/ajtmh.14-0161

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  28 in total

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6.  Multidrug-resistant tuberculosis in Port-au-Prince, Haiti.

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2.  Potentially High Number of Ineffective Drugs with the Standard Shorter Course Regimen for Multidrug-Resistant Tuberculosis Treatment in Haiti.

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Review 4.  Time to treatment for rifampicin-resistant tuberculosis: systematic review and meta-analysis.

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5.  Comorbidities and treatment outcomes in multidrug resistant tuberculosis: a systematic review and meta-analysis.

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9.  Survival Status and Predictors of Mortality among Multidrug-Resistant Tuberculosis Patients in Saint Peter's Specialized Hospital, Addis Ababa, Ethiopia.

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  10 in total

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