Literature DB >> 25071000

Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic Burkitt lymphoma.

Cliff I Oduor1, Kiprotich Chelimo1, Collins Ouma1, David H Mulama1, Joslyn Foley1, John Vulule1, Jeffrey A Bailey1, Ann M Moormann2.   

Abstract

Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences in cytokine production. We hypothesized that children genetically predisposed for elevated cytokine levels may be more susceptible to eBL. Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the association between eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes. In addition, the association between these variants and Epstein Barr Virus (EBV) load was examined. Results showed that selected IL-10 and IL-6 promoter SNPs and IL-10 promoter haplotypes were not associated with risk eBL or EBV levels in EBV-seropositive children. Findings from this study reveal that common variants within the IL-10 and IL-6 promoters do not independently increase eBL risk in this vulnerable population. © The American Society of Tropical Medicine and Hygiene.

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Year:  2014        PMID： 25071000      PMCID： PMC4155573          DOI： 10.4269/ajtmh.13-0616

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  45 in total

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Journal:  J Infect Dis       Date:  2002-09-13       Impact factor: 5.226

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Authors:  S L Ferrari; L Ahn-Luong; P Garnero; S E Humphries; S L Greenspan
Journal:  J Clin Endocrinol Metab       Date:  2003-01       Impact factor: 5.958

10.  Sickle cell trait is not associated with endemic Burkitt lymphoma: an ethnicity and malaria endemicity-matched case-control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer.

Authors:  David H Mulama; Jeffrey A Bailey; Joslyn Foley; Kiprotich Chelimo; Collins Ouma; Walter G Z O Jura; Juliana Otieno; John Vulule; Ann M Moormann
Journal:  Int J Cancer       Date:  2013-08-16       Impact factor: 7.396
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