Literature DB >> 2507088

Actions of arachidonic acid and hepoxilin A3 on mammalian hippocampal CA1 neurons.

P L Carlen1, N Gurevich, P H Wu, W G Su, E J Corey, C R Pace-Asciak.   

Abstract

The effects of arachidonic acid and its lipoxygenase metabolites, the hepoxilins, were investigated in rat hippocampal CA1 neurons in vitro by intracellular electrophysiological recordings. Both arachidonic acid and the hepoxilins cause a hyperpolarization which is sometimes followed by a later depolarization, augment the postspike train long-lasting afterhyperpolarization (AHP) and increase orthodromic inhibitory postsynaptic potentials (IPSPs). These data show that this arachidonic acid metabolic pathway has significant actions on mammalian central neurons, and may represent an important mechanism of neuromodulation.

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Year:  1989        PMID： 2507088     DOI： 10.1016/0006-8993(89)90984-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels.

Authors:  Y Takahashi; H Kawajiri; T Yoshimoto; N Hoshi; H Higashida
Journal:  J Physiol       Date:  1999-12-15       Impact factor: 5.182

2.  Characterization of human 12-lipoxygenase genes.

Authors:  C D Funk; L B Funk; G A FitzGerald; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

Review 3.  The hepoxilins and some analogues: a review of their biology.

Authors:  Cecil R Pace-Asciak
Journal:  Br J Pharmacol       Date:  2009-04-30       Impact factor: 8.739

4.  Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils.

Authors:  S Dho; S Grinstein; E J Corey; W G Su; C R Pace-Asciak
Journal:  Biochem J       Date:  1990-02-15       Impact factor: 3.857

5.  Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus.

Authors:  L Pellerin; L S Wolfe
Journal:  Neurochem Res       Date:  1991-09       Impact factor: 3.996

Review 6.  Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.

Authors:  C R Pace-Asciak; D Reynaud; P M Demin
Journal:  Lipids       Date:  1995-02       Impact factor: 1.880

7.  Arachidonic acid and its acyclic derivatives regulate short-term plasticity of the cholinoreceptors of neurons of the edible snail.

Authors:  A S Pivovarov; E I Drozdova; B I Kotlyar
Journal:  Neurosci Behav Physiol       Date:  1992 Sep-Oct

8.  Hepoxilin A3 is the endogenous lipid mediator opposing hypotonic swelling of intact human platelets.

Authors:  A Margalit; Y Sofer; S Grossman; D Reynaud; C R Pace-Asciak; A A Livne
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

9.  Roles of arachidonic acid, lipoxygenases and phosphatases in calcium-dependent modulation of M-current in bullfrog sympathetic neurons.

Authors:  S P Yu
Journal:  J Physiol       Date:  1995-09-15       Impact factor: 5.182

10.  Hepoxilin A3-specific binding in human neutrophils.

Authors:  D Reynaud; P Demin; C R Pace-Asciak
Journal:  Biochem J       Date:  1996-01-15       Impact factor: 3.857
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