Literature DB >> 25070718

Pin1: a molecular orchestrator in the heart.

Nirmala Hariharan1, Mark A Sussman2.   

Abstract

Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25070718      PMCID： PMC4150822          DOI： 10.1016/j.tcm.2014.05.010

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  42 in total

1.  Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells.

Authors:  Frank Eckerdt; Juping Yuan; Krishna Saxena; Bernd Martin; Sven Kappel; Christine Lindenau; Andrea Kramer; Steffen Naumann; Sebastian Daum; Gunter Fischer; Ivan Dikic; Manfred Kaufmann; Klaus Strebhardt
Journal:  J Biol Chem       Date:  2005-08-23       Impact factor: 5.157

2.  Raf phosphorylation: one step forward and two steps back.

Authors:  Nicolas Dumaz; Richard Marais
Journal:  Mol Cell       Date:  2005-01-21       Impact factor: 17.970

3.  Regulation of Raf-1 by direct feedback phosphorylation.

Authors:  Michele K Dougherty; Jürgen Müller; Daniel A Ritt; Ming Zhou; Xiao Zhen Zhou; Terry D Copeland; Thomas P Conrads; Timothy D Veenstra; Kun Ping Lu; Deborah K Morrison
Journal:  Mol Cell       Date:  2005-01-21       Impact factor: 17.970

Review 4.  Prolyl cis-trans isomerization as a molecular timer.

Authors:  Kun Ping Lu; Greg Finn; Tae Ho Lee; Linda K Nicholson
Journal:  Nat Chem Biol       Date:  2007-10       Impact factor: 15.040

5.  The prolyl isomerase Pin1 functions in mitotic chromosome condensation.

Authors:  Yu-Xin Xu; James L Manley
Journal:  Mol Cell       Date:  2007-04-27       Impact factor: 17.970

Review 6.  Regulation of cardiac hypertrophy by intracellular signalling pathways.

Authors:  Joerg Heineke; Jeffery D Molkentin
Journal:  Nat Rev Mol Cell Biol       Date:  2006-08       Impact factor: 94.444

7.  The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

Authors:  P J Lu; G Wulf; X Z Zhou; P Davies; K P Lu
Journal:  Nature       Date:  1999-06-24       Impact factor: 49.962

8.  The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.

Authors:  M Shen; P T Stukenberg; M W Kirschner; K P Lu
Journal:  Genes Dev       Date:  1998-03-01       Impact factor: 11.361

9.  Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis.

Authors:  Futoshi Suizu; Akihide Ryo; Gerburg Wulf; Jormay Lim; Kun Ping Lu
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

10.  Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance.

Authors:  Tae Ho Lee; Adrian Tun-Kyi; Rong Shi; Jormay Lim; Christina Soohoo; Greg Finn; Martin Balastik; Lucia Pastorino; Gerburg Wulf; Xiao Zhen Zhou; Kun Ping Lu
Journal:  Nat Cell Biol       Date:  2008-12-07       Impact factor: 28.824
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  7 in total

Review 1.  Recent Developments in Heart Failure.

Authors:  Sujith Dassanayaka; Steven P Jones
Journal:  Circ Res       Date:  2015-09-11       Impact factor: 17.367

2.  Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.

Authors:  Sara Helander; Meri Montecchio; Robert Pilstål; Yulong Su; Jacob Kuruvilla; Malin Elvén; Javed M E Ziauddin; Madhanagopal Anandapadamanaban; Susana Cristobal; Patrik Lundström; Rosalie C Sears; Björn Wallner; Maria Sunnerhagen
Journal:  Structure       Date:  2015-11-19       Impact factor: 5.006

Review 3.  The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.

Authors:  Xiao Zhen Zhou; Kun Ping Lu
Journal:  Nat Rev Cancer       Date:  2016-06-03       Impact factor: 60.716

4.  Impact of PIN1 Inhibition on Tumor Progression and Chemotherapy Sensitivity in Colorectal Cancer.

Authors:  Saeideh Gholamzadeh Khoei; Massoud Saidijam; Razieh Amini; Akram Jalali; Rezvan Najafi
Journal:  J Gastrointest Cancer       Date:  2021-02-13

5.  Pin1 facilitates isoproterenol‑induced cardiac fibrosis and collagen deposition by promoting oxidative stress and activating the MEK1/2‑ERK1/2 signal transduction pathway in rats.

Authors:  Xian Wu; Mingjiang Li; Su-Qin Chen; Sha Li; Furong Guo
Journal:  Int J Mol Med       Date:  2017-12-29       Impact factor: 4.101

Review 6.  Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis.

Authors:  Jingyi Li; Chunfen Mo; Yifan Guo; Bowen Zhang; Xiao Feng; Qiuyue Si; Xiaobo Wu; Zhe Zhao; Lixin Gong; Dan He; Jichun Shao
Journal:  Theranostics       Date:  2021-01-19       Impact factor: 11.556

7.  Peptidyl-Prolyl Isomerase 1 Regulates Ca2+ Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na2+/Ca2+ Exchanger 1 Protein Levels and Function.

Authors:  Veronica Sacchi; Bingyan J Wang; Dieter Kubli; Alexander S Martinez; Jung-Kang Jin; Roberto Alvarez; Nirmala Hariharan; Christopher Glembotski; Takafumi Uchida; James S Malter; Yijun Yang; Polina Gross; Chen Zhang; Steven Houser; Marcello Rota; Mark A Sussman
Journal:  J Am Heart Assoc       Date:  2017-10-10       Impact factor: 5.501
  7 in total

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