Ian M Ward1, Eric M Mortensen2, Daniel F Battafarano3, Christopher R Frei4, Ishak Mansi5. 1. San Antonio Military Medical Center and the San Antonio Uniformed Services Health Consortium, Ft Sam Houston, TX, USA. 2. VA North Texas Health Care System, Dallas, TX, USA University of Texas Southwestern Medical Center, Dallas, TX, USA. 3. San Antonio Uniformed Services Health Education Consortium Brooke Army Medical Center, San Antonio, TX, USA. 4. The University of Texas at Austin, Austin, TX, USA The University of Texas Health Science Center, San Antonio, TX, USA. 5. VA North Texas Health Care System, Dallas, TX, USA University of Texas Southwestern Medical Center, Dallas, TX, USA Ishak.mansi@va.gov.
Abstract
BACKGROUND: Contradictory evidence exists regarding statin use and risk of osteoporotic fractures. OBJECTIVE: The study objective was to examine the effect of statins on fracture risk in a Military Healthcare System (MHS) with similar access and standard of health care for its beneficiaries. METHODS: This is a retrospective study of patients enrolled in an MHS encompassing the period from October 1, 2003, to March 1, 2010. Statin users were defined as those receiving a statin for ≥90 days in Fiscal Year 2005, whereas nonusers were defined as individuals not receiving a statin throughout the study period. A propensity score-matched cohort of statin users and nonusers was created using 42 variables. The outcomes were identified using ICD-9-CM codes in the follow-up period (October 1, 2006, to March 1, 2010). In all, 4 outcomes were examined: all fractures, femoral neck fractures, upper-extremity fractures, and lower-extremity fractures. RESULTS: Of 46 249 patients, 6967 pairs of statin users and nonusers were matched. Statin users had a lower risk of femoral neck fracture in comparison to nonusers (odds ratio=0.58, 95% CI=0.36-0.94) but similar risk of all fractures, lower-extremity fractures, and upper-extremity fractures. CONCLUSIONS: In this cohort of patients managed in an MHS, statin use was associated with a lower risk of femoral neck fractures, but not all fractures, upper-extremity fractures, or lower-extremity fractures.
BACKGROUND: Contradictory evidence exists regarding statin use and risk of osteoporotic fractures. OBJECTIVE: The study objective was to examine the effect of statins on fracture risk in a Military Healthcare System (MHS) with similar access and standard of health care for its beneficiaries. METHODS: This is a retrospective study of patients enrolled in an MHS encompassing the period from October 1, 2003, to March 1, 2010. Statin users were defined as those receiving a statin for ≥90 days in Fiscal Year 2005, whereas nonusers were defined as individuals not receiving a statin throughout the study period. A propensity score-matched cohort of statin users and nonusers was created using 42 variables. The outcomes were identified using ICD-9-CM codes in the follow-up period (October 1, 2006, to March 1, 2010). In all, 4 outcomes were examined: all fractures, femoral neck fractures, upper-extremity fractures, and lower-extremity fractures. RESULTS: Of 46 249 patients, 6967 pairs of statin users and nonusers were matched. Statin users had a lower risk of femoral neck fracture in comparison to nonusers (odds ratio=0.58, 95% CI=0.36-0.94) but similar risk of all fractures, lower-extremity fractures, and upper-extremity fractures. CONCLUSIONS: In this cohort of patients managed in an MHS, statin use was associated with a lower risk of femoral neck fractures, but not all fractures, upper-extremity fractures, or lower-extremity fractures.
Authors: Chandan Vangala; Colin R Lenihan; Maria E Montez-Rath; Sumi Sukumaran Nair; Sankar D Navaneethan; Venkat Ramanathan; Wolfgang C Winkelmayer Journal: BMC Nephrol Date: 2017-05-01 Impact factor: 2.388
Authors: Michael Leutner; Caspar Matzhold; Luise Bellach; Carola Deischinger; Jürgen Harreiter; Stefan Thurner; Peter Klimek; Alexandra Kautzky-Willer Journal: Ann Rheum Dis Date: 2019-09-26 Impact factor: 19.103