Fang Fang1, Jian Pan1, Lixiao Xu1, Guanghao Su1, Gang Li1, Jian Wang2. 1. Institute of Pediatric Research, Children's Hospital of Soochow University, China. 2. Institute of Pediatric Research, Children's Hospital of Soochow University, China wj196312@vip.163.com.
Abstract
OBJECTIVE: Many studies have focused on the relationship between the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism and pancreatitis risk, but the results remain inconsistent. Thus, a meta-analysis was carried out to derive a more precise estimation of the association between ACE I/D polymorphism and pancreatitis risk. METHODS: Relevant publications were searched in several widely used databases and seven studies from six eligible articles were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between ACE I/D polymorphism and pancreatitis risk. RESULTS: Significant associations between ACE I/D polymorphism and pancreatitis risk were observed in both overall meta-analysis for DI versus II (OR=0.80, 95% CI=0.67-0.96) and DD + DI versus II (OR=0.83, 95% CI=0.70-0.98), and acute pancreatitis subgroup for DI versus II (OR=0.65, 95% CI=0.44-0.95). However, no significant pancreatitis risk variation was detected for all genetic models in the subgroup meta-analysis based on ethnicity. CONCLUSIONS: According to the results of our meta-analysis, the ACE I/D polymorphism probably associates with pancreatitis risk, especially acute pancreatitis risk, with the I allele acting as a risk factor.
OBJECTIVE: Many studies have focused on the relationship between the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism and pancreatitis risk, but the results remain inconsistent. Thus, a meta-analysis was carried out to derive a more precise estimation of the association between ACE I/D polymorphism and pancreatitis risk. METHODS: Relevant publications were searched in several widely used databases and seven studies from six eligible articles were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between ACE I/D polymorphism and pancreatitis risk. RESULTS: Significant associations between ACE I/D polymorphism and pancreatitis risk were observed in both overall meta-analysis for DI versus II (OR=0.80, 95% CI=0.67-0.96) and DD + DI versus II (OR=0.83, 95% CI=0.70-0.98), and acute pancreatitis subgroup for DI versus II (OR=0.65, 95% CI=0.44-0.95). However, no significant pancreatitis risk variation was detected for all genetic models in the subgroup meta-analysis based on ethnicity. CONCLUSIONS: According to the results of our meta-analysis, the ACE I/D polymorphism probably associates with pancreatitis risk, especially acute pancreatitis risk, with the I allele acting as a risk factor.