Cheryl Klaiman1, Eve-Marie Quintin2, Booil Jo3, Amy A Lightbody3, Heather Cody Hazlett4, Joseph Piven4, Scott S Hall3, Lindsay C Chromik, Allan L Reiss5. 1. Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, Georgia;Emory University, School of Medicine, Atlanta, Georgia; Cheryl.klaiman@emory.edu. 2. Georgia Institute of Technology, School of Psychology, Atlanta, Georgia; 3. Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California; 4. Carolina Institute for Developmental Disabilities, andDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. 5. Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;Departments of Radiology, andPediatrics, Stanford University, Palo Alto, California; and.
Abstract
OBJECTIVE: To examine longitudinally the adaptive behavior patterns in fragile X syndrome. METHOD: Caregivers of 275 children and adolescents with fragile X syndrome and 225 typically developing children and adolescents (2-18 years) were interviewed with the Vineland Adaptive Behavior Scales every 2 to 4 years as part of a prospective longitudinal study. RESULTS: Standard scores of adaptive behavior in people with fragile X syndrome are marked by a significant decline over time in all domains for males and in communication for females. Socialization skills are a relative strength as compared with the other domains for males with fragile X syndrome. Females with fragile X syndrome did not show a discernible pattern of developmental strengths and weaknesses. CONCLUSIONS: This is the first large-scale longitudinal study to show that the acquisition of adaptive behavior slows as individuals with fragile X syndrome age. It is imperative to ensure that assessments of adaptive behavior skills are part of intervention programs focusing on childhood and adolescence in this condition.
OBJECTIVE: To examine longitudinally the adaptive behavior patterns in fragile X syndrome. METHOD: Caregivers of 275 children and adolescents with fragile X syndrome and 225 typically developing children and adolescents (2-18 years) were interviewed with the Vineland Adaptive Behavior Scales every 2 to 4 years as part of a prospective longitudinal study. RESULTS: Standard scores of adaptive behavior in people with fragile X syndrome are marked by a significant decline over time in all domains for males and in communication for females. Socialization skills are a relative strength as compared with the other domains for males with fragile X syndrome. Females with fragile X syndrome did not show a discernible pattern of developmental strengths and weaknesses. CONCLUSIONS: This is the first large-scale longitudinal study to show that the acquisition of adaptive behavior slows as individuals with fragile X syndrome age. It is imperative to ensure that assessments of adaptive behavior skills are part of intervention programs focusing on childhood and adolescence in this condition.
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