Susan S Chiu1, Pak-Leung Ho2, Pek-Lan Khong3, Clara Ooi3, Lok Yee So4, Wilfred H S Wong5, Eunice L Y Chan5. 1. Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China. Electronic address: ssschiu@hkkucc.hku.hk. 2. Department of Microbiology, University of Hong Kong, Hong Kong SAR, China. 3. Department of Diagnostic Radiology, University of Hong Kong, Hong Kong SAR, China. 4. Department of Pediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong SAR, China. 5. Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China.
Abstract
OBJECTIVES: We sought to document the incidence of pediatric hospitalization for bacterial pneumonia before universal childhood conjugate pneumococcal vaccination using two different methods of diagnosis. METHODS: By following the World Health Organization (WHO) chest radiography (CXR) protocol, two radiologists independently read the CXRs of a cohort of systematically recruited children younger than 5 years. The children had acute respiratory infections and were admitted to one of two hospitals that care for 72.5% of all pediatric admissions on Hong Kong Island. Medical records were reviewed for clinical manifestation and to identify bacterial pneumonia diagnosed by pediatricians. RESULTS: In children younger than 5 years, the incidences of bacterial pneumonia, as diagnosed by pediatricians and by the WHO CXR standard, were 775.7 per 100,000 population [95% confidence interval (CI, 591.8-998.3)] and 439.5 per 100,000 population (95% CI, 304.6-614.5), respectively. The study period was from 2002 to 2004. CONCLUSION: This study provided a reliable baseline estimate of the hospitalization burden of pneumococcal pneumonia in Hong Kong children before the advent of universal conjugate pneumococcal vaccination.
OBJECTIVES: We sought to document the incidence of pediatric hospitalization for bacterial pneumonia before universal childhood conjugate pneumococcal vaccination using two different methods of diagnosis. METHODS: By following the World Health Organization (WHO) chest radiography (CXR) protocol, two radiologists independently read the CXRs of a cohort of systematically recruited children younger than 5 years. The children had acute respiratory infections and were admitted to one of two hospitals that care for 72.5% of all pediatric admissions on Hong Kong Island. Medical records were reviewed for clinical manifestation and to identify bacterial pneumonia diagnosed by pediatricians. RESULTS: In children younger than 5 years, the incidences of bacterial pneumonia, as diagnosed by pediatricians and by the WHO CXR standard, were 775.7 per 100,000 population [95% confidence interval (CI, 591.8-998.3)] and 439.5 per 100,000 population (95% CI, 304.6-614.5), respectively. The study period was from 2002 to 2004. CONCLUSION: This study provided a reliable baseline estimate of the hospitalization burden of pneumococcal pneumonia in Hong Kong children before the advent of universal conjugate pneumococcal vaccination.
Authors: Xue Li; Joseph E Blais; Ian C K Wong; Anthony W Y Tam; Benjamin J Cowling; Ivan F N Hung; Esther W Y Chan Journal: Eur J Clin Microbiol Infect Dis Date: 2019-01-25 Impact factor: 3.267
Authors: Susan S Chiu; Benjamin J Cowling; J S Malik Peiris; Eunice L Y Chan; Wilfred H S Wong; Kwok Piu Lee Journal: Emerg Infect Dis Date: 2022-01 Impact factor: 6.883