[Research advances in the effects of excise and diet on LPL and its mechanism].

Lipoprotein lipase (LPL) plays a major role in the metabolism and transport of lipids by hydrolyzing core triglycerides (TG) in chylomicrons and very low density lipoprotein. LPL is mainly synthesized and secreted by fat cells, myocardial cells and skeletal muscle cells. The expression and activity of LPL are regulated by multiple factors, such as hormones, nutrition, exercise, PPARgamma, apolipoproteins, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) and angiopoietin-like proteins (ANGPTL). After introducing advance in LPL structure and regulation, we review the effects of exercise and diet intervention on the expression and activity of LPL and its possible mechanism.