Sophie Hennion1, Xavier Delbeuck2, Alain Duhamel3, Renaud Lopes4, Franck Semah5, Louise Tyvaert1, Philippe Derambure1, William Szurhaj1. 1. Epilepsy Unit, Department of Clinical Neurophysiology, Lille University Medical Center. 2. Department of Neurology, Lille University Medical Center. 3. Department of Public Health, Lille University Medical Center. 4. Department of Neuroradiology, Institute of Predictive Medicine and Therapeutic Research, Lille University Medical Center. 5. Department of Nuclear Medicine, Lille University Medical Center.
Abstract
OBJECTIVE: Patients with temporal lobe epilepsy (TLE) have impaired theory of mind (ToM). However, ToM involves a variety of processes, such as understanding a person's intentions ("cognitive" ToM) and emotional states ("affective" ToM). The objectives of the present study were to characterize ToM disorders in TLE patients, identify patients at risk of ToM disorders, and study the relationships between psychobehavioral and quality of life factors and ToM disorders. METHOD: Fifty TLE patients and 50 controls performed ToM tasks assessing their understanding of verbal clumsiness (faux pas), sarcastic remarks, and mentalistic actions. Demographic, cognitive, and psychobehavioral data, and (for TLE patients) clinical and quality of life factors, were recorded. RESULTS: Compared with controls, TLE patients showed impairments in all ToM tasks: 84% misunderstood faux pas, and around 50% misunderstood sarcasm. A long duration of epilepsy and young age at onset were risk factors for ToM impairments. In TLE patients, ToM impairments were associated with impaired empathy and anhedonia. Their affective states were less positively and more negatively valenced than in controls. Low positive affectivity was predictive of greater cognitive and affective ToM impairments for the faux pas task, and high negative affectivity was predictive of greater cognitive ToM abilities for the sarcasm task. The lack of social support was correlated with impaired ToM but was not a predictive factor. CONCLUSIONS: Both cognitive and affective ToM processes are impaired in TLE patients. Impaired ToM has an impact on empathy abilities and is related to affective disturbances in TLE patients. (c) 2015 APA, all rights reserved).
OBJECTIVE:Patients with temporal lobe epilepsy (TLE) have impaired theory of mind (ToM). However, ToM involves a variety of processes, such as understanding a person's intentions ("cognitive" ToM) and emotional states ("affective" ToM). The objectives of the present study were to characterize ToM disorders in TLEpatients, identify patients at risk of ToM disorders, and study the relationships between psychobehavioral and quality of life factors and ToM disorders. METHOD: Fifty TLEpatients and 50 controls performed ToM tasks assessing their understanding of verbal clumsiness (faux pas), sarcastic remarks, and mentalistic actions. Demographic, cognitive, and psychobehavioral data, and (for TLEpatients) clinical and quality of life factors, were recorded. RESULTS: Compared with controls, TLEpatients showed impairments in all ToM tasks: 84% misunderstood faux pas, and around 50% misunderstood sarcasm. A long duration of epilepsy and young age at onset were risk factors for ToM impairments. In TLEpatients, ToM impairments were associated with impaired empathy and anhedonia. Their affective states were less positively and more negatively valenced than in controls. Low positive affectivity was predictive of greater cognitive and affective ToM impairments for the faux pas task, and high negative affectivity was predictive of greater cognitive ToM abilities for the sarcasm task. The lack of social support was correlated with impaired ToM but was not a predictive factor. CONCLUSIONS: Both cognitive and affective ToM processes are impaired in TLEpatients. Impaired ToM has an impact on empathy abilities and is related to affective disturbances in TLEpatients. (c) 2015 APA, all rights reserved).
Authors: Michele Morningstar; Andy Hung; Connor Grannis; Roberto C French; Whitney I Mattson; Adam P Ostendorf; Satyanarayana Gedela; Dario J Englot; Eric E Nelson Journal: Epilepsy Behav Date: 2020-09-09 Impact factor: 2.937
Authors: Birgitta Metternich; Kathrin Wagner; Maximilian J Geiger; Andreas Schulze-Bonhage; Martin Hirsch; Michael Schönenberg Journal: Front Psychiatry Date: 2022-07-11 Impact factor: 5.435