| Literature DB >> 2506678 |
R D Stoner1, W H Adams, D N Slatkin, H W Siegelman.
Abstract
Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity.Entities:
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Year: 1989 PMID： 2506678 DOI： 10.1016/0041-0101(89)90051-2
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033