Rajendra H Mehta1, Cynthia M Westerhout2, Yinggan Zheng2, Robert P Giugliano3, Kurt Huber4, Dorairaj Prabhakaran5, Robert A Harrington6, Kristin L Newby7, Paul W Armstrong2. 1. Duke Clinical Research Institute, Durham, NC. Electronic address: mehta007@dcri.duke.edu. 2. Canadian VIGOUR Centre at the University of Alberta, Edmonton, Alberta, Canada. 3. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 4. Department of Medicine, Wilhelminenspital, Vienna, Austria. 5. Centre for Chronic Disease Control, New Delhi, India. 6. Department of Medicine, Stanford University, Stanford, CA. 7. Duke Clinical Research Institute, Durham, NC.
Abstract
BACKGROUND: The relationship of metabolic syndrome and its individual components (obesity, hypertension, glucose intolerance, high triglycerides, and low high-density lipoprotein cholesterol) with 1-year mortality in non-ST-segment elevation acute coronary syndromes (NSTE ACS) patients is not known. METHODS: The association of metabolic syndrome (and its individual components) with all-cause mortality within 1 year was assessed in NSTE ACS patients enrolled in the EARLY ACS trial. Adjusted hazard ratio (HR) and 95% CIs are reported. RESULTS: Of 9,406 patients, 2,596 (27.6%) had metabolic syndrome. Compared with those without metabolic syndrome, patients with this syndrome were younger, were more often female, and had a higher prevalence of comorbid conditions and higher-risk presenting features. Metabolic syndrome was not associated with increased 1-year mortality (HR 1.20, 95% CI 0.97-1.47; P = .09). The risk of 1-year mortality varied across the individual components: high-density lipoprotein <40 mg/dL (men)/<50 mg/dL (women; or dyslipidemia) was associated with higher risk (HR 1.52, 95% CI 1.15-2.02), and triglycerides >150 mg/dL (or dyslipidemia) was associated with lower risk (HR 0.66, 95% CI 0.54-0.81), whereas the other components (ie, body mass index >30 kg/m(2), fasting plasma glucose >100 mg/dL or diabetes, systolic blood pressure >130 mm Hg or diastolic >85 mm Hg [or hypertension]) were associated with neutral risk of this event. CONCLUSIONS: The individual components of metabolic syndrome had varying associations with 1-year mortality, and as an integrated diagnosis, metabolic syndrome was not significantly associated with 1-year mortality. Thus, patient case-mix of the studied NSTE ACS population may influence the observed relationship of metabolic syndrome with subsequent cardiovascular events.
BACKGROUND: The relationship of metabolic syndrome and its individual components (obesity, hypertension, glucose intolerance, high triglycerides, and low high-density lipoprotein cholesterol) with 1-year mortality in non-ST-segment elevation acute coronary syndromes (NSTE ACS) patients is not known. METHODS: The association of metabolic syndrome (and its individual components) with all-cause mortality within 1 year was assessed in NSTE ACSpatients enrolled in the EARLY ACS trial. Adjusted hazard ratio (HR) and 95% CIs are reported. RESULTS: Of 9,406 patients, 2,596 (27.6%) had metabolic syndrome. Compared with those without metabolic syndrome, patients with this syndrome were younger, were more often female, and had a higher prevalence of comorbid conditions and higher-risk presenting features. Metabolic syndrome was not associated with increased 1-year mortality (HR 1.20, 95% CI 0.97-1.47; P = .09). The risk of 1-year mortality varied across the individual components: high-density lipoprotein <40 mg/dL (men)/<50 mg/dL (women; or dyslipidemia) was associated with higher risk (HR 1.52, 95% CI 1.15-2.02), and triglycerides >150 mg/dL (or dyslipidemia) was associated with lower risk (HR 0.66, 95% CI 0.54-0.81), whereas the other components (ie, body mass index >30 kg/m(2), fasting plasma glucose >100 mg/dL or diabetes, systolic blood pressure >130 mm Hg or diastolic >85 mm Hg [or hypertension]) were associated with neutral risk of this event. CONCLUSIONS: The individual components of metabolic syndrome had varying associations with 1-year mortality, and as an integrated diagnosis, metabolic syndrome was not significantly associated with 1-year mortality. Thus, patient case-mix of the studied NSTE ACS population may influence the observed relationship of metabolic syndrome with subsequent cardiovascular events.
Authors: Theodora W Elffers; Renée de Mutsert; Hildo J Lamb; Arie C Maan; Peter W Macfarlane; Ko Willems van Dijk; Frits R Rosendaal; J Wouter Jukema; Stella Trompet Journal: Diabetol Metab Syndr Date: 2017-05-22 Impact factor: 3.320