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Literature DB >> 2506646

The spectrum of monoclonal immunoglobulin deposition disease associated with immunocytic dyscrasias.

G Gallo¹, M Picken, J Buxbaum, B Frangione.

Abstract

Immunocytic dyscrasias may be manifested by MIDD often presenting with renal manifestations. The diagnosis is established when deposits are shown by immunopathologic methods to contain a single light-chain isotype in patients who have a monoclonal Ig in the serum or urine, altered kappa:lambda ratio in bone marrow, and/or abnormal biosynthesis of Igs in bone marrow cell cultures. The morphologic expressions of deposits are varied: fibrillar in AL, granular and punctate in LCDD, granular or crystalline in LHCDD, and crystalline in type I cryoglobulinemia.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2506646

Source DB: PubMed Journal: Semin Hematol ISSN： 0037-1963 Impact factor: 3.851

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Cited

11 in total

1. Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.

Authors: R Vidal; F Goñi; F Stevens; P Aucouturier; A Kumar; B Frangione; J Ghiso; G Gallo
Journal: Am J Pathol Date: 1999-12 Impact factor: 4.307

2. Primary structure of a monoclonal kappa chain in myeloma with light chain deposition disease.

Authors: A A Khamlichi; P Aucouturier; C Silvain; M Bauwens; G Touchard; J L Preud'homme; F Nau; M Cogné
Journal: Clin Exp Immunol Date: 1992-01 Impact factor: 4.330

3. The effect of membranes on the in vitro fibrillation of an amyloidogenic light-chain variable-domain SMA.

Authors: Xiaoyun Meng; Anthony L Fink; Vladimir N Uversky
Journal: J Mol Biol Date: 2008-06-28 Impact factor: 5.469

4. Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease.

Authors: M Cogné; J L Preud'homme; M Bauwens; G Touchard; P Aucouturier
Journal: J Clin Invest Date: 1991-06 Impact factor: 14.808

10. Effect of methionine oxidation on the structural properties, conformational stability, and aggregation of immunoglobulin light chain LEN.

Authors: Dongmei Hu; Zhijie Qin; Bin Xue; Anthony L Fink; Vladimir N Uversky
Journal: Biochemistry Date: 2008-07-25 Impact factor: 3.162

The spectrum of monoclonal immunoglobulin deposition disease associated with immunocytic dyscrasias.

1. Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.

2. Primary structure of a monoclonal kappa chain in myeloma with light chain deposition disease.

3. The effect of membranes on the in vitro fibrillation of an amyloidogenic light-chain variable-domain SMA.

4. Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease.

Review 5. Molecular anatomy and the pathological expression of antibody light chains.

6. A role for destabilizing amino acid replacements in light-chain amyloidosis.

7. Potential role of apolipoprotein-E in fibrillogenesis.

8. AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences.

9. Light chain cardiomyopathy. Structural analysis of the light chain tissue deposits.

10. Effect of methionine oxidation on the structural properties, conformational stability, and aggregation of immunoglobulin light chain LEN.